Increased Beat-to-Beat Variability of T-Wave Heterogeneity Measured From Standard 12-Lead Electrocardiogram Is Associated With Sudden Cardiac Death: A Case-Control Study.
T-wave
T-wave morphology
electrocardiography
repolarization
sudden cardiac death
ventricular arrhythmias
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2020
2020
Historique:
received:
09
06
2020
accepted:
29
07
2020
entrez:
28
9
2020
pubmed:
29
9
2020
medline:
29
9
2020
Statut:
epublish
Résumé
The prognostic significance of beat-to-beat variability of spatial heterogeneity of repolarization measured from standard 12-lead ECG is not well-understood. We measured the short-term variability of repolarization parameters, such as T-wave heterogeneity in leads V4-V6 (TWH) and QT interval (QT), from five consecutive beats of previously recorded standard 12-lead ECG in 200 victims of unexpected sudden cardiac death (SCD) confirmed to be due to complicated atherosclerotic coronary artery disease (CAD) in medico-legal autopsy and 200 age- and sex-matched controls with angiographically confirmed CAD. The short-term variability of repolarization heterogeneity was defined as the standard deviation (SD) of the measured repolarization parameters. All ECGs were in sinus rhythm, and no premature ventricular contractions were included in the measured segment. TWH-SD and QT-SD were significantly higher in SCD victims than in subjects with CAD (6.9 ± 5.6 μV vs. 3.8 ± 2.6 μV, Increased short-term variability of repolarization heterogeneity measured from standard 12-lead ECG is associated with SCD.
Identifiants
pubmed: 32982784
doi: 10.3389/fphys.2020.01045
pmc: PMC7477294
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1045Informations de copyright
Copyright © 2020 Hekkanen, Kenttä, Haukilahti, Rahola, Holmström, Vähätalo, Tulppo, Kiviniemi, Pakanen, Ukkola, Junttila, Huikuri and Perkiömäki.
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