Evolutionary Approaches to Combat Antibiotic Resistance: Opportunities and Challenges for Precision Medicine.
Animals
Anti-Bacterial Agents
/ therapeutic use
Antimicrobial Stewardship
Bacteria
/ drug effects
Bacterial Infections
/ drug therapy
Bacterial Proteins
/ genetics
Drug Resistance, Bacterial
/ genetics
Evolution, Molecular
Gene Expression Regulation, Bacterial
Host-Pathogen Interactions
Humans
Precision Medicine
AMR
drug resistance
evolution
evolutionary medicine
precision medicine
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
01
06
2020
accepted:
17
07
2020
entrez:
28
9
2020
pubmed:
29
9
2020
medline:
20
4
2021
Statut:
epublish
Résumé
The rise of antimicrobial resistance (AMR) in bacterial pathogens is acknowledged by the WHO as a major global health crisis. It is estimated that in 2050 annually up to 10 million people will die from infections with drug resistant pathogens if no efficient countermeasures are implemented. Evolution of pathogens lies at the core of this crisis, which enables rapid adaptation to the selective pressures imposed by antimicrobial usage in both medical treatment and agriculture, consequently promoting the spread of resistance genes or alleles in bacterial populations. Approaches developed in the field of Evolutionary Medicine attempt to exploit evolutionary insight into these adaptive processes, with the aim to improve diagnostics and the sustainability of antimicrobial therapy. Here, we review the concept of evolutionary trade-offs in the development of AMR as well as new therapeutic approaches and their impact on host-microbiome-pathogen interactions. We further discuss the possible translation of evolution-informed treatments into clinical practice, considering both the rapid cure of the individual patients and the prevention of AMR.
Identifiants
pubmed: 32983122
doi: 10.3389/fimmu.2020.01938
pmc: PMC7481325
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bacterial Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1938Informations de copyright
Copyright © 2020 Merker, Tueffers, Vallier, Groth, Sonnenkalb, Unterweger, Baines, Niemann and Schulenburg.
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