Experimental Models for the Study of Central Nervous System Infection by SARS-CoV-2.
COVID-19
SARS-CoV-2
central nervous system
experimental models
multiple sclerosis
neurodegenerative disease
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
Historique:
received:
19
06
2020
accepted:
10
08
2020
entrez:
28
9
2020
pubmed:
29
9
2020
medline:
21
10
2020
Statut:
epublish
Résumé
The response to the SARS-CoV-2 coronavirus epidemic requires increased research efforts to expand our knowledge of the disease. Questions related to infection rates and mechanisms, the possibility of reinfection, and potential therapeutic approaches require us not only to use the experimental models previously employed for the SARS-CoV and MERS-CoV coronaviruses but also to generate new models to respond to urgent questions. We reviewed the different experimental models used in the study of central nervous system (CNS) involvement in COVID-19 both in different cell lines that have enabled identification of the virus' action mechanisms and in animal models (mice, rats, hamsters, ferrets, and primates) inoculated with the virus. Specifically, we reviewed models used to assess the presence and effects of SARS-CoV-2 on the CNS, including neural cell lines, animal models such as mouse hepatitis virus CoV (especially the 59 strain), and the use of brain organoids. Given the clear need to increase our understanding of SARS-CoV-2, as well as its potential effects on the CNS, we must endeavor to obtain new information with cellular or animal models, with an appropriate resemblance between models and human patients.
Identifiants
pubmed: 32983181
doi: 10.3389/fimmu.2020.02163
pmc: PMC7485091
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2163Informations de copyright
Copyright © 2020 Sanclemente-Alaman, Moreno-Jiménez, Benito-Martín, Canales-Aguirre, Matías-Guiu, Matías-Guiu and Gómez-Pinedo.
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