Potential role of cellular miRNAs in coronavirus-host interplay.
COVID-19
Coronavirus
SARS-CoV-2
miR-16-5p
miR-195-5p
miR-21-3p
miR-3065-5p
miR-421
miR-424-5p
miRNA
Journal
PeerJ
ISSN: 2167-8359
Titre abrégé: PeerJ
Pays: United States
ID NLM: 101603425
Informations de publication
Date de publication:
2020
2020
Historique:
received:
08
07
2020
accepted:
28
08
2020
entrez:
28
9
2020
pubmed:
29
9
2020
medline:
29
9
2020
Statut:
epublish
Résumé
Host miRNAs are known as important regulators of virus replication and pathogenesis. They can interact with various viruses through several possible mechanisms including direct binding of viral RNA. Identification of human miRNAs involved in coronavirus-host interplay becomes important due to the ongoing COVID-19 pandemic. In this article we performed computational prediction of high-confidence direct interactions between miRNAs and seven human coronavirus RNAs. As a result, we identified six miRNAs (miR-21-3p, miR-195-5p, miR-16-5p, miR-3065-5p, miR-424-5p and miR-421) with high binding probability across all analyzed viruses. Further bioinformatic analysis of binding sites revealed high conservativity of miRNA binding regions within RNAs of human coronaviruses and their strains. In order to discover the entire miRNA-virus interplay we further analyzed lungs miRNome of SARS-CoV infected mice using publicly available miRNA sequencing data. We found that miRNA miR-21-3p has the largest probability of binding the human coronavirus RNAs and being dramatically up-regulated in mouse lungs during infection induced by SARS-CoV.
Identifiants
pubmed: 32983652
doi: 10.7717/peerj.9994
pii: 9994
pmc: PMC7497610
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e9994Informations de copyright
© 2020 Nersisyan et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
Références
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
Nucleic Acids Res. 2020 Jan 8;48(D1):D148-D154
pubmed: 31647101
Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):941-6
pubmed: 22215596
Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5
pubmed: 23193258
Nat Commun. 2019 Sep 27;10(1):4397
pubmed: 31562301
Trends Mol Med. 2017 Jan;23(1):80-93
pubmed: 27989642
Obes Rev. 2019 Jan;20(1):108-118
pubmed: 30248223
Eur J Endocrinol. 2019 Jul 01;181(1):69-78
pubmed: 31096184
Trends Genet. 2007 May;23(5):243-9
pubmed: 17368621
Annu Rev Pathol. 2014;9:287-314
pubmed: 24079833
PLoS One. 2015 Dec 31;10(12):e0145930
pubmed: 26720041
Nucleic Acids Res. 2015 Jul 1;43(W1):W460-6
pubmed: 25977294
Cell. 2009 Feb 20;136(4):642-55
pubmed: 19239886
Nucleic Acids Res. 2019 Jan 8;47(D1):D155-D162
pubmed: 30423142
mBio. 2011 Nov 15;2(6):
pubmed: 22086488
Cell Discov. 2017 Jun 27;3:17021
pubmed: 28690868
Genome Biol. 2013 Jul 29;14(7):R78
pubmed: 23895045
Lancet. 2020 Apr 11;395(10231):1225-1228
pubmed: 32178769
Lancet Respir Med. 2020 Apr;8(4):420-422
pubmed: 32085846
J Biol Chem. 2015 Feb 27;290(9):5381-90
pubmed: 25568327
Cancer Biol Ther. 2019;20(6):897-911
pubmed: 30862230
Front Genet. 2015 Jun 30;6:232
pubmed: 26175755
EMBO Rep. 2015 Apr;16(4):500-11
pubmed: 25724380
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
Oncotarget. 2016 Jun 14;7(24):36321-36337
pubmed: 27166999
Nature. 2014 Jul 31;511(7511):543-50
pubmed: 25079552
Genome Biol. 2014;15(12):550
pubmed: 25516281
Front Cell Infect Microbiol. 2018 May 25;8:175
pubmed: 29888214
Front Mol Biosci. 2019 Nov 08;6:122
pubmed: 31781574
Nucleic Acids Res. 2012 Jan;40(1):37-52
pubmed: 21911355
Bioinformatics. 2012 Apr 15;28(8):1166-7
pubmed: 22368248
PLoS One. 2020 Jul 29;15(7):e0235987
pubmed: 32726325
Front Immunol. 2019 Feb 28;10:202
pubmed: 30873152
Nat Methods. 2020 Mar;17(3):261-272
pubmed: 32015543
Neurosci Lett. 2009 Dec 4;466(2):55-62
pubmed: 19393715
Sci Rep. 2017 Nov 27;7(1):16422
pubmed: 29180670
Nucleic Acids Res. 2011 Jan;39(Database issue):D19-21
pubmed: 21062823
Nature. 2005 Jul 7;436(7047):112-6
pubmed: 16001071
Cell Host Microbe. 2016 Mar 9;19(3):409-23
pubmed: 26962949
Cell Host Microbe. 2017 Mar 8;21(3):344-355
pubmed: 28216251
Nucleic Acids Res. 2020 Jan 8;48(D1):D127-D131
pubmed: 31504780
PLoS One. 2013 Sep 30;8(9):e75628
pubmed: 24098708
Front Microbiol. 2017 May 15;8:824
pubmed: 28555130
Nucleic Acids Res. 2019 Jan 8;47(D1):D766-D773
pubmed: 30357393
RNA Biol. 2014;11(7):875-90
pubmed: 24922324
RNA. 2012 Nov;18(11):2041-55
pubmed: 23019594
Nucleic Acids Res. 2017 Jan 4;45(D1):D482-D490
pubmed: 27899678
Nucleic Acids Res. 2009 Feb;37(3):858-65
pubmed: 19103665
Aging Dis. 2020 May 9;11(3):509-522
pubmed: 32489698
Glob Chall. 2017 Jan 10;1(1):33-46
pubmed: 31565258
BMC Microbiol. 2014 Sep 30;14:252
pubmed: 25266911
Elife. 2015 Aug 12;4:
pubmed: 26267216
Nature. 2014 Feb 13;506(7487):245-8
pubmed: 24352241