Trends in the Treatment Outcomes and Features of Cryptorchidism in Boys: A Single-Institute Experience.
cryptorchidism
hypospadias
orchiopexy
pediatrics
spontaneous resolution
Journal
Research and reports in urology
ISSN: 2253-2447
Titre abrégé: Res Rep Urol
Pays: England
ID NLM: 101576971
Informations de publication
Date de publication:
2020
2020
Historique:
received:
12
07
2020
accepted:
29
08
2020
entrez:
28
9
2020
pubmed:
29
9
2020
medline:
29
9
2020
Statut:
epublish
Résumé
Cryptorchidism is one of the most common congenital abnormalities in pediatric urology, and orchiopexy is performed for the prevention of testicular damage and malignant transformation. We examined the distribution and outcomes of cryptorchidism under a single investigator at our institute. This retrospective study included 283 boys diagnosed with cryptorchidism at our institute. Cryptorchidism was diagnosed based on the medical history and physical examination findings. Boys without spontaneous resolution after 6 months of age were indicated for orchiopexy. We investigated the 12-year trend in the distribution and outcomes of cryptorchidism at the institute. The mean age at diagnosis, gestational age, and birth weight were 2 years, 37 weeks, and 2740 g, respectively. A total of 170 boys underwent orchiopexy under 2 years of age, and 136 boys underwent orchiopexy under the age of 1 year, while 62 boys underwent orchiopexy over the age of 3 years. Abnormalities of the epididymis and disclosure of the processus vaginalis were observed in 44 (25%) and 72 boys (41%), respectively. Comparison of boys with or without hypospadias showed that the age at orchiopexy was higher in boys with hypospadias than in those without hypospadias (P=0.028). In addition, boys without hypospadias had a higher rate of abnormality of the epidermis than those with hypospadias (P=0.024). Our findings suggest that most boys with cryptorchidism are treated under the age of 2 years and the incidence of epididymal abnormality is relatively high, especially in boys with hypospadias. An understanding of the natural features of cryptorchidism could lead to better management and outcomes. Further research is warranted to develop an appropriate treatment timeline in boys with cryptorchidism.
Identifiants
pubmed: 32984085
doi: 10.2147/RRU.S271869
pii: 271869
pmc: PMC7508029
doi:
Types de publication
Journal Article
Langues
eng
Pagination
373-381Informations de copyright
© 2020 Hori et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
Références
BJU Int. 2006 Oct;98(4):854-7
pubmed: 16978284
J Urol. 1993 Mar;149(3):570-3
pubmed: 8094761
J Pediatr Urol. 2019 Feb;15(1):41.e1-41.e9
pubmed: 30459092
Hum Reprod. 2001 May;16(5):972-8
pubmed: 11331648
J Urol. 1996 Dec;156(6):2054-6
pubmed: 8911389
J Urol. 2011 Jun;185(6 Suppl):2444-50
pubmed: 21555006
J Pediatr Urol. 2013 Dec;9(6 Pt A):815-9
pubmed: 23218756
Lancet. 1986 May 31;1(8492):1246-8
pubmed: 2872394
Nat Rev Urol. 2017 Sep;14(9):534-548
pubmed: 28654092
J Endocrinol Invest. 2002 Sep;25(8):709-15
pubmed: 12240903
BMC Urol. 2015 Oct 24;15:108
pubmed: 26497933
N Engl J Med. 2007 May 3;356(18):1835-41
pubmed: 17476009
J Urol. 2004 Feb;171(2 Pt 1):849-51
pubmed: 14713841
Urol Int. 2008;81(2):210-4
pubmed: 18758222
J Urol. 2002 Jul;168(1):229-32
pubmed: 12050549
Epidemiology. 1999 Jul;10(4):364-9
pubmed: 10401869
Int J Urol. 2007 Jul;14(7):616-21
pubmed: 17645605
Nat Rev Urol. 2011 Apr;8(4):187-96
pubmed: 21403659
Pediatrics. 1993 Jul;92(1):44-9
pubmed: 8100060
Horm Res. 2001;55(1):6-10
pubmed: 11423735
J Pediatr Surg. 2013 May;48(5):903-8
pubmed: 23701757