Toward a Closed Loop, Integrated Biocompatible Biopolymer Wound Dressing Patch for Detection and Prevention of Chronic Wound Infections.

Polyhydroxyalkanoates Pseudomonas aeruginosa artificial intelligence biopolymer electrochemical graphene pyocyanin wound dressing

Journal

Frontiers in bioengineering and biotechnology
ISSN: 2296-4185
Titre abrégé: Front Bioeng Biotechnol
Pays: Switzerland
ID NLM: 101632513

Informations de publication

Date de publication:
2020
Historique:
received: 29 04 2020
accepted: 11 08 2020
entrez: 28 9 2020
pubmed: 29 9 2020
medline: 29 9 2020
Statut: epublish

Résumé

Chronic wound infections represent a significant burden to healthcare providers globally. Often, chronic wound healing is impeded by the presence of infection within the wound or wound bed. This can result in an increased healing time, healthcare cost and poor patient outcomes. Thus, there is a need for dressings that help the wound heal, in combination with early detection of wound infections to support prompt treatment. In this study, we demonstrate a novel, biocompatible wound dressing material, based on Polyhydroxyalkanoates, doped with graphene platelets, which can be used as an electrochemical sensing substrate for the detection of a common wound pathogen,

Identifiants

pubmed: 32984295
doi: 10.3389/fbioe.2020.01039
pmc: PMC7493637
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1039

Informations de copyright

Copyright © 2020 Ward, Dubey, Basnett, Lika, Newman, Corrigan, Russell, Kim, Chakrabarty, Connolly and Roy.

Références

Microb Biotechnol. 2017 Nov;10(6):1384-1399
pubmed: 28905518
Burns. 2009 Jun;35(4):500-8
pubmed: 19286324
Diagnostics (Basel). 2020 Feb 16;10(2):
pubmed: 32079129
Annu Rev Phytopathol. 2006;44:417-45
pubmed: 16719720
J Biomater Appl. 2016 Mar;30(8):1273-82
pubmed: 26873635
Biomaterials. 2006 May;27(15):2944-50
pubmed: 16443271
Rev Infect Dis. 1983 Mar-Apr;5(2):279-313
pubmed: 6405475
Eur J Clin Microbiol. 1985 Apr;4(2):219-23
pubmed: 3924612
Int Wound J. 2006 Sep;3(3):225-31
pubmed: 16984578
Neural Netw. 2015 Jan;61:85-117
pubmed: 25462637
J Clin Microbiol. 2008 Aug;46(8):2717-22
pubmed: 18508940
Biomaterials. 2003 Mar;24(6):1041-5
pubmed: 12504526
J Biomater Sci Polym Ed. 2003;14(10):1029-42
pubmed: 14661877
Int J Low Extrem Wounds. 2019 Sep;18(3):247-261
pubmed: 31257948
Appl Environ Microbiol. 2008 Apr;74(7):2171-8
pubmed: 18245232
Antonie Van Leeuwenhoek. 2007 Jan;91(1):1-17
pubmed: 17016742
Macromol Biosci. 2013 Sep;13(9):1119-34
pubmed: 23982911
PLoS One. 2014 Mar 10;9(3):e91732
pubmed: 24614411
Dokl Biol Sci. 2002 Mar-Apr;383:109-11
pubmed: 12053558
J Appl Microbiol. 2008 Jun;104(6):1624-35
pubmed: 18194257
Burns. 2006 Aug;32(5):545-9
pubmed: 16797127
Infect Immun. 1988 Sep;56(9):2515-7
pubmed: 3137173
Burns. 2014 Aug;40(5):835-41
pubmed: 24296064
Trends Biotechnol. 2019 Jul;37(7):775-788
pubmed: 30683459
Bioelectrochemistry. 2010 Feb;77(2):114-9
pubmed: 19666245
Wound Repair Regen. 2016 Mar;24(2):366-72
pubmed: 26815644
Int J Biol Macromol. 1999 Jun-Jul;25(1-3):111-21
pubmed: 10416657
Anal Chem. 2018 Jun 19;90(12):7761-7768
pubmed: 29851349
Small. 2018 Jul 6;:e1703509
pubmed: 29978547
Biomaterials. 2005 Jun;26(17):3537-48
pubmed: 15621244
ACS Appl Mater Interfaces. 2018 Aug 1;10(30):25056-25068
pubmed: 29965724
J Clin Microbiol. 1981 Mar;13(3):456-8
pubmed: 6787067
Expert Rev Anti Infect Ther. 2015 May;13(5):605-13
pubmed: 25746414
Biosci Biotechnol Biochem. 2011;75(8):1615-7
pubmed: 21821924
Int J Surg. 2007 Oct;5(5):316-22
pubmed: 17499032
Nat Commun. 2014;5:3256
pubmed: 24510163
Biomaterials. 2007 Sep;28(27):3896-903
pubmed: 17574664
J Microbiol Biotechnol. 2015 Nov;25(11):1936-43
pubmed: 26198125
Science. 2008 Aug 29;321(5893):1203-6
pubmed: 18755976
JMIR Diabetes. 2018 Jun 21;3(2):e11
pubmed: 30291078
Sensors (Basel). 2016 Mar 19;16(3):
pubmed: 27007376
PLoS One. 2011;6(12):e29113
pubmed: 22216178
Bull Math Biol. 2001 Jan;63(1):95-116
pubmed: 11146885
Environ Sci Technol. 2008 Apr 1;42(7):2380-6
pubmed: 18504969
Appl Microbiol Biotechnol. 2007 Jan;73(5):969-79
pubmed: 17123079
J Mater Sci Mater Med. 2018 Nov 30;29(12):179
pubmed: 30506294
Trends Mol Med. 2004 Dec;10(12):599-606
pubmed: 15567330
Polymers (Basel). 2018 Jul 03;10(7):
pubmed: 30960656
Adv Wound Care (New Rochelle). 2015 Sep 1;4(9):560-582
pubmed: 26339534

Auteurs

Andrew C Ward (AC)

Department of Biomedical Engineering, Faculty of Engineering, University of Strathclyde, Glasgow, United Kingdom.

Prachi Dubey (P)

School of Life Sciences, College of Liberal Arts and Sciences, University of Westminster, London, United Kingdom.

Pooja Basnett (P)

School of Life Sciences, College of Liberal Arts and Sciences, University of Westminster, London, United Kingdom.

Granit Lika (G)

School of Life Sciences, College of Liberal Arts and Sciences, University of Westminster, London, United Kingdom.

Gwenyth Newman (G)

Department of Biomedical Engineering, Faculty of Engineering, University of Strathclyde, Glasgow, United Kingdom.

Damion K Corrigan (DK)

Department of Biomedical Engineering, Faculty of Engineering, University of Strathclyde, Glasgow, United Kingdom.

Christopher Russell (C)

Vivisco Pvt Ltd, London, United Kingdom.

Jongrae Kim (J)

School of Mechanical Engineering, Faculty of Engineering, University of Leeds, Leeds, United Kingdom.

Samit Chakrabarty (S)

School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.

Patricia Connolly (P)

Department of Biomedical Engineering, Faculty of Engineering, University of Strathclyde, Glasgow, United Kingdom.

Ipsita Roy (I)

Department of Materials Science and Engineering, Faculty of Engineering, The University of Sheffield, Sheffield, United Kingdom.

Classifications MeSH