Pak1ip1 Loss-of-Function Leads to Cell Cycle Arrest, Loss of Neural Crest Cells, and Craniofacial Abnormalities.

Pak1ip1 development mouse neural crest orofacial clefts ribosomopathies

Journal

Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250

Informations de publication

Date de publication:
2020
Historique:
received: 05 11 2019
accepted: 13 08 2020
entrez: 28 9 2020
pubmed: 29 9 2020
medline: 29 9 2020
Statut: epublish

Résumé

Neural crest cells (NCCs) comprise a transient progenitor cell population of neuroepithelial origin that contributes to a variety of cell types throughout vertebrate embryos including most mesenchymal cells of the cranial and facial structures. Consequently, abnormal NCC development underlies a variety of craniofacial defects including orofacial clefts, which constitute some of the most common birth defects. We previously reported the generation of

Identifiants

pubmed: 32984348
doi: 10.3389/fcell.2020.510063
pmc: PMC7490522
doi:

Types de publication

Journal Article

Langues

eng

Pagination

510063

Subventions

Organisme : NIDCR NIH HHS
ID : R01 DE022830
Pays : United States

Informations de copyright

Copyright © 2020 Panoutsopoulos, De Crescenzo, Lee, Lu, Ross, Borodinsky, Marcucio, Trainor and Zarbalis.

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Auteurs

Alexios A Panoutsopoulos (AA)

Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Davis, CA, United States.
Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children - Northern California, Sacramento, CA, United States.

Angelo Harlan De Crescenzo (AH)

Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Davis, CA, United States.
Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children - Northern California, Sacramento, CA, United States.

Albert Lee (A)

Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Davis, CA, United States.
Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children - Northern California, Sacramento, CA, United States.

Amelia MacKenzie Lu (AM)

David B. Falk College of Sport and Human Dynamics - Department of Public Health, Syracuse University, Syracuse, NY, United States.

Adam P Ross (AP)

Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Davis, CA, United States.
Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children - Northern California, Sacramento, CA, United States.

Laura N Borodinsky (LN)

Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children - Northern California, Sacramento, CA, United States.
Department of Physiology and Membrane Biology, School of Medicine, University of California, Davis, Davis, CA, United States.

Ralph Marcucio (R)

Department of Orthopedic Surgery, School of Medicine, University of California, San Francisco, San Francisco, CA, United States.

Paul A Trainor (PA)

Stowers Institute for Medical Research, Kansas City, MO, United States.
Department of Anatomy and Cell Biology, School of Medicine, The University of Kansas Medical Center, Kansas, KS, United States.

Konstantinos S Zarbalis (KS)

Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Davis, CA, United States.
Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children - Northern California, Sacramento, CA, United States.
MIND Institute, University of California, Davis, Davis, CA, United States.

Classifications MeSH