Emerging RNA-Dependent RNA Polymerase Mutation in a Remdesivir-Treated B-cell Immunodeficient Patient With Protracted Coronavirus Disease 2019.

Adenosine Monophosphate / analogs & derivatives Aged Alanine / analogs & derivatives B-Lymphocytes COVID-19 / therapy Female Humans Immunization, Passive Mutation RNA-Dependent RNA Polymerase SARS-CoV-2 COVID-19 Drug Treatment COVID-19 Serotherapy
COVID-19 RNA-dependent RNA-polymerase mutation SARS-CoV-2 convalescent plasma remdesivir

Journal

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
ISSN: 1537-6591
Titre abrégé: Clin Infect Dis
Pays: United States
ID NLM: 9203213

Informations de publication

Date de publication:
05 10 2021
Historique:
received: 26 08 2020
pubmed: 29 9 2020
medline: 12 10 2021
entrez: 28 9 2020
Statut: ppublish

Résumé

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly discovered virus for which remdesivir is the only antiviral available. We report the occurrence of a mutation in RdRP (D484Y) following treatment with remdesivir in a 76-year-old female with post-rituximab B-cell immunodeficiency and persistent SARS-CoV-2 viremia. A cure was achieved after supplementation with convalescent plasma.

Identifiants

DOI: 10.1093/cid/ciaa1474 PMID: 32986807 PMC: PMC7543308
pubmed: 32986807
pii: 5912587
doi: 10.1093/cid/ciaa1474
pmc: PMC7543308
doi:

Substances chimiques

remdesivir 3QKI37EEHE
Adenosine Monophosphate 415SHH325A
RNA-Dependent RNA Polymerase EC 2.7.7.48
Alanine OF5P57N2ZX

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e1762-e1765

Informations de copyright

© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Auteurs

Martin Martinot (M)

Infectious Diseases Department, Hôpitaux Civils de Colmar, Colmar, France.
ORCID: 0000-0003-4524-9064

Aude Jary (A)

Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP, Pitié-Salpêtrière Hospital, Department of Virology, Paris, France.

Samira Fafi-Kremer (S)

Virology Laboratory, Strasbourg University Hospital, Strasbourg, France.
Strasbourg University, INSERM, IRM UMR-S 1109, F-67000 Strasbourg, France.

Valentin Leducq (V)

Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP, Pitié-Salpêtrière Hospital, Department of Virology, Paris, France.

Heloise Delagreverie (H)

Virology Laboratory, Strasbourg University Hospital, Strasbourg, France.
Strasbourg University, INSERM, IRM UMR-S 1109, F-67000 Strasbourg, France.
ORCID: 0000-0001-8700-9996

Marc Garnier (M)

Sorbonne Université, GRC 29, APHP, DMU DREAM, Anesthesiology and Intensive Care Department, Saint-Antoine Hospital, Paris, France.

Jérôme Pacanowski (J)

Infectious Diseases Department, Saint-Antoine Hospital, APHP - Sorbonne Université, Paris, France.

Arsène Mékinian (A)

Sorbonne Université, Internal Medicine Department, Inflammation-Immunopathology-Biotherapy Department (DMU i3D), Saint-Antoine Hospital, AP-HP, Paris, France.
ORCID: 0000-0003-2849-3049

France Pirenne (F)

Etablissement Français du Sang, La Plaine St-Denis - France.
Institut Mondor de Recherche Biomédicale, Unité 955, Equipe 2: Transfusion et Maladies du Globule Rouge, INSERM, EFS, Université Paris-Est Créteil, Créteil, France.

Pierre Tiberghien (P)

Etablissement Français du Sang, La Plaine St-Denis - France.
UMR 1098 RIGHT Inserm Université de Franche-Comté Etablissement Français du Sang, Besançon.

Vincent Calvez (V)

Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP, Pitié-Salpêtrière Hospital, Department of Virology, Paris, France.

Catherine Humbrecht (C)

Etablissement Français du sang Grand Est, Strasbourg, France.

Anne-Geneviève Marcelin (AG)

Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP, Pitié-Salpêtrière Hospital, Department of Virology, Paris, France.

Karine Lacombe (K)

Sorbonne Université, Inserm IPLESP, Infectious Diseases Department, Saint-Antoine Hospital, APHP, Paris, France.

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › AMP › Emerging RNA-Dependent RNA Polymerase Mutation...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Emerging RNA-Dependent RNA Polymerase Mutation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Alanine › Emerging RNA-Dependent RNA Polymerase Mutation...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › Emerging RNA-Dependent RNA Polymerase Mutation...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Emerging RNA-Dependent RNA Polymerase Mutation...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Emerging RNA-Dependent RNA Polymerase Mutation...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunisation passive › Emerging RNA-Dependent RNA Polymerase Mutation...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Emerging RNA-Dependent RNA Polymerase Mutation...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › RNA nucleotidyltransferases › RNA replicase › Emerging RNA-Dependent RNA Polymerase Mutation...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Emerging RNA-Dependent RNA Polymerase Mutation...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Traitements médicamenteux de la COVID-19 › Emerging RNA-Dependent RNA Polymerase Mutation...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunisation passive › Transfert adoptif › Sérothérapie COVID-19 › Emerging RNA-Dependent RNA Polymerase Mutation...