Discrimination of phenethylamine regioisomers and structural analogues by Raman spectroscopy.
Raman spectroscopy
characteristic peak
new psychoactive substances
phenethylamines
regioisomers
structural analogues
Journal
Journal of forensic sciences
ISSN: 1556-4029
Titre abrégé: J Forensic Sci
Pays: United States
ID NLM: 0375370
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
18
06
2020
revised:
04
08
2020
accepted:
10
08
2020
pubmed:
29
9
2020
medline:
29
9
2020
entrez:
28
9
2020
Statut:
ppublish
Résumé
In this study, the Raman spectra of 21 phenethylamines were obtained using far-red excitation (785 nm). The distinguishing ability of Raman for phenethylamines, especially for phenethylamine regioisomers and structural analogues, was investigated. Here, the evaluation of a cross section of Raman spectra demonstrated that all types of phenethylamines were distinguishable, even for certain structural analogues with high spectrum similarity. Raman exhibited high distinguishing ability for phenethylamine regioisomers that differ in the substitution position of halogen, methoxy, alkyl, or other substituted groups; as well as for structural analogues containing different groups, such as furanyl, 2,3-dihydrofuranyl, halogen, and alkyl substituted at the same position. The Raman spectra for homologues with differences in only a methyl group were found to be highly similar; however, their spectra demonstrated small but detectable differences. Four analogue mixtures and 59 seized samples were also analyzed to study the practical use of the Raman method in forensic field. 95% of the seized samples were correctly identified, which significantly validated the ability of Raman method in identifying the correct isomers. Accordingly, this study provides a non-destructive, high-throughput and minimal sample preparation technique for the discrimination of phenethylamines.
Identifiants
pubmed: 32986857
doi: 10.1111/1556-4029.14563
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
365-374Subventions
Organisme : the National Key Research and Development Program of China
ID : 2016YFC0800903
Informations de copyright
© 2020 American Academy of Forensic Sciences.
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