Reorganization of action observation and sensory-motor networks after action observation therapy in children with congenital hemiplegia: A pilot study.
Fmri
action observation network
action observation therapy
congenital hemiplegia
rehabilitation
sensory-motor system
upper limb
Journal
Developmental neurobiology
ISSN: 1932-846X
Titre abrégé: Dev Neurobiol
Pays: United States
ID NLM: 101300215
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
07
05
2020
revised:
08
09
2020
accepted:
08
09
2020
pubmed:
29
9
2020
medline:
26
10
2021
entrez:
28
9
2020
Statut:
ppublish
Résumé
New rehabilitation programs based on action observation therapy (AOT) are effective in improving motor function in children with congenital hemiplegia. In this pilot study we tested the potential effects of AOT on the reorganization of the motor system by functional magnetic resonance imaging (fMRI). As part of a randomized trial, eight subjects (age range: 6.2-14.5 years) with congenital hemiplegia were randomly assigned to an experimental (EG) or control (CG) group. All children underwent a clinical and neurophysiological assessment with Assisting Hand Assessment (AHA), MRI, and fMRI at baseline (T0), 1(T1), and 8(T2) weeks after the end of 3-week treatment. For the EG, AOT consisted in the observation of uni/bimanual goal-directed actions followed by their execution. CG watched same-duration computer games and then performed the same actions in the same order used in the EG. fMRI study was carried out using two different paradigms, for exploring sensory-motor network (SMN) localization and action observation network (AON). The pattern of brain activation was generally similar between T0 and T1 for both groups, while it was more widespread at T2, compared to T0 and T1, in the EG. This enlargement was coupled with functional improvement at AHA. Single-subject analysis shows a reduction of lateralization indexes both for the AON and the SMN. This pilot study, despite the small sample, showed the fMRI feasibility for providing relevant biomarkers of brain plasticity for monitoring the AOT response in children with congenital hemiplegia. The study was registered at http://www.clinicaltrials.gov (identifier NCT01016496).
Banques de données
ClinicalTrials.gov
['NCT01016496']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
351-360Subventions
Organisme : Italian Ministry of Health
ID : GR-2011-02350053
Organisme : Italian Ministry of Health
ID : RC2019
Organisme : Italian Ministry of Health
ID : 5 X 1000 health Research 2015
Informations de copyright
© 2020 Wiley Periodicals, LLC.
Références
Beani, E., Menici, V., Ferrari, A., Cioni, G., & Sgandurra, G. (2020). Feasibility of a home-based action observation training for children with unilateral cerebral palsy: An explorative study. Frontiers in Neurology, 11, 16. https://doi.org/10.3389/fneur.2020.00016
Biagi, L., Cioni, G., Fogassi, L., Guzzetta, A., Sgandurra, G., & Tosetti, M. (2016). Action observation network in childhood: A comparative fMRI study with adults. Developmental Science, 19, 1075-1086. https://doi.org/10.1111/desc.12353
Biagi, L., Cioni, G., Fogassi, L., Guzzetta, A., & Tosetti, M. (2010). Anterior intraparietal cortex codes complexity of observed hand movements. Brain Research Bulletin, 81, 434-440. https://doi.org/10.1016/j.brainresbull.2009.12.002
Buccino, G., Arisi, D., Gough, P., Aprile, D., Ferri, C., Serotti, L., Tiberti, A., & Fazzi, E. (2012). Improving upper limb motor functions through action observation treatment: A pilot study in children with cerebral palsy. Developmental Medicine and Child Neurology, 54, 822-828. https://doi.org/10.1111/j.1469-8749.2012.04334.x
Buccino, G., Molinaro, A., Ambrosi, C., Arisi, D., Mascaro, L., Pinardi, C., Rossi, A., Gasparotti, R., Fazzi, E., & Galli, J. (2018). Action observation treatment improves upper limb motor functions in children with cerebral palsy: A combined clinical and brain imaging study. Neural Plasticity, 2018, 1-11. https://doi.org/10.1155/2018/4843985
Buchignani, B., Beani, E., Pomeroy, V., Iacono, O., Sicola, E., Perazza, S., Bieber, E., Feys, H., Klingels, K., Cioni, G., & Sgandurra, G. (2019). Action observation training for rehabilitation in brain injuries: A systematic review and meta-analysis. BMC Neurology, 19(1), https://doi.org/10.1186/s12883-019-1533-x
Cioni, G., Sales, B., Paolicelli, P. B., Petacchi, E., Scusa, M. F., & Canapicchi, R. (1999). MRI and clinical characteristics of children with hemiplegic cerebral palsy. Neuropediatrics, 30, 249-255. https://doi.org/10.1055/s-2007-973499
Cioni, G., Sgandurra, G., Muzzini, S., Paolicelli, P. B., & Ferrari, A. (2009). Forms of hemiplegia. In A. Ferrari, & G. Cioni (Eds.), The spastic forms of cerebral palsy. A guide to the assessment of adaptive functions (pp. 331-353). Springer-Verlag.
Ertelt, D., Small, S., Solodkin, A., Dettmers, C., McNamara, A., Binkofski, F., & Buccino, G. (2007). Action observation has a positive impact on rehabilitation of motor deficits after stroke. NeuroImage, 36(Suppl 2), T164-T173. https://doi.org/10.1016/j.neuroimage.2007.03.043
Fabbri-Destro, M., & Rizzolatti, G. (2008). Mirror neurons and mirror systems in monkeys and humans. Physiology (Bethesda), 2, 171-179. https://doi.org/10.1152/physiol.00004.2008
Franceschini, M., Agosti, M., Cantagallo, A., Sale, P., Mancuso, M., & Buccino, G. (2010). Mirror neurons: Action observation treatment as a tool in stroke rehabilitation. European Journal of Physical and Rehabilitation Medicine, 46, 517-523.
Gallese, V., Fadiga, L., Fogassi, L., & Rizzolatti, G. (1996). Action recognition in the premotor cortex. Brain, 119(Pt 2), 593-609. https://doi.org/10.1093/brain/119.2.593
Guzzetta, A., Pecini, C., Biagi, L., Tosetti, M., Brizzolara, D., Chilosi, A., Cipriani, P., Petacchi, E., & Cioni, G. (2008). Language organisation in left perinatal stroke. Neuropediatrics, 39(3), 157-163. https://doi.org/10.1055/s-0028-1085465
Klingels, K., de Cock, P., Molenaers, G., Desloovere, K., Huenaerts, C., Jaspers, E., & Feys, H. (2010). Upper limb motor and sensory impairments in children with hemiplegic cerebral palsy. Can they be measured reliably? Disability and Rehabilitation., 32(5), 409-416. https://doi.org/10.3109/09638280903171469
Krägeloh-Mann, I., & Cans, C. (2009). Cerebral palsy update. Brain & Development, 7, 537-544.
Moher, D., Hopewell, S., Schulz, K. F., Montori, V., Gøtzsche, P. C., Devereaux, P. J., Elbourne, D., Egger, M., & Altman, D. G. (2012). CONSORT 2010 explanation and elaboration: Updated guidelines for reporting parallel group randomised trials. International Journal of Surgery, 10, 28-55. https://doi.org/10.1016/j.ijsu.2011.10.001
Novak, I., & Honan, I. (2019). Effectiveness of paediatric occupational therapy for children with disabilities: A systematic review. Australian Occupational Therapy Journal, 66, 258-273. https://doi.org/10.1111/1440-1630.12573
Quadrelli, E., Anzani, A., Ferri, M., Bolognini, N., Maravita, A., Zambonin, F., & Turati, C. (2019). Electrophysiological correlates of action observation treatment in children with cerebral palsy: A pilot study. Developmental Neurobiology, 79, 934-948. https://doi.org/10.1002/dneu.22734
Seghier, M. L. (2008). Laterality index in functional MRI: Methodological issues. Magnetic Resonance Imaging, 26, 594-601. https://doi.org/10.1016/j.mri.2007.10.010
Sgandurra, G., Biagi, L., Fogassi, L., Sicola, E., Ferrari, A., Guzzetta, A., Tosetti, M., & Cioni, G. (2018). Reorganization of the action observation network and sensory-motor system in children with unilateral cerebral palsy: An fMRI study. Neural Plasticity, 2018, 1-15. https://doi.org/10.1155/2018/6950547
Sgandurra, G., Cecchi, F., Beani, E., Mannari, I., Maselli, M., Falotico, F. P., & Cioni, G. (2018). Tele-UPCAT: Study protocol of a randomised controlled trial of a home-based Tele-monitored UPper limb Children Action observation Training for participants with unilateral cerebral palsy. British Medical Journal Open, 8, e017819. https://doi.org/10.1136/bmjopen-2017-017819
Sgandurra, G., Ferrari, A., Cossu, G., Guzzetta, A., Biagi, L., Tosetti, M., Fogassi, L., & Cioni, G. (2011). Upper limb children action-observation training (UPCAT): A randomised controlled trial in Hemiplegic Cerebral Palsy. BMC Neurology, 11, 80. https://doi.org/10.1186/1471-2377-11-80
Sgandurra, G., Ferrari, A., Cossu, G., Guzzetta, A., Fogassi, L., & Cioni, G. (2013). Randomized trial of observation and execution of upper extremity actions versus action alone in children with unilateral cerebral palsy. Neurorehabilitation and Neural Repair, 27(9), 808-815. https://doi.org/10.1177/1545968313497101
Weinstein, M., Myers, V., Green, D., Schertz, M., Shiran, S. I., Geva, R., Artzi, M., Gordon, A. M., Fattal-Valevski, A., & Ben Bashat, D. (2015). Brain plasticity following intensive bimanual therapy in children with hemiparesis: Preliminary evidence. Neural Plasticity, 2015, 1-13. https://doi.org/10.1155/2015/798481