ECG changes at rest and during exercise in lowlanders with COPD travelling to 3100 m.
Chronic obstructive pulmonary disease (COPD)
Electrocardiogram (ECG)
Exercise
High altitude
Hypoxia
Ischemia
Journal
International journal of cardiology
ISSN: 1874-1754
Titre abrégé: Int J Cardiol
Pays: Netherlands
ID NLM: 8200291
Informations de publication
Date de publication:
01 02 2021
01 02 2021
Historique:
received:
24
06
2020
revised:
08
09
2020
accepted:
20
09
2020
pubmed:
29
9
2020
medline:
28
5
2021
entrez:
28
9
2020
Statut:
ppublish
Résumé
The incidence and magnitude of cardiac ischemia and arrhythmias in patients with chronic obstructive pulmonary disease (COPD) during exposure to hypobaric hypoxia is insufficiently studied. We investigated electrocardiogram (ECG) markers of ischemia at rest and during incremental exercise testing (IET) in COPD-patients travelling to 3100 m. Lowlanders (residence <800 m) with COPD (forced volume in the first second of expiration (FEV 80 COPD-patients (51% women, mean ± SD, 56.2 ± 9.6 years, body mass index (BMI) 27.0 ± 4.5 kg/m In this study, ECG recordings at rest and during IET in COPD-patients do not suggest an increased incidence of signs of ischemia with ascent to 3100 m. Whether statistically significant ST changes below the standard threshold of clinical relevance detected in multiple leads reflect a risk of ischemia during prolonged exposure remains to be elucidated.
Sections du résumé
BACKGROUND
The incidence and magnitude of cardiac ischemia and arrhythmias in patients with chronic obstructive pulmonary disease (COPD) during exposure to hypobaric hypoxia is insufficiently studied. We investigated electrocardiogram (ECG) markers of ischemia at rest and during incremental exercise testing (IET) in COPD-patients travelling to 3100 m.
STUDY DESIGN AND METHODS
Lowlanders (residence <800 m) with COPD (forced volume in the first second of expiration (FEV
RESULTS
80 COPD-patients (51% women, mean ± SD, 56.2 ± 9.6 years, body mass index (BMI) 27.0 ± 4.5 kg/m
CONCLUSION
In this study, ECG recordings at rest and during IET in COPD-patients do not suggest an increased incidence of signs of ischemia with ascent to 3100 m. Whether statistically significant ST changes below the standard threshold of clinical relevance detected in multiple leads reflect a risk of ischemia during prolonged exposure remains to be elucidated.
Identifiants
pubmed: 32987054
pii: S0167-5273(20)33836-5
doi: 10.1016/j.ijcard.2020.09.055
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
173-179Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None of the authors report any conflict of interest in relation to this manuscript. Prof. Dr. med. S. Ulrich(1) reports grants from Johnson and Johnson SA, Switzerland, during the conduct of the study; grants from Swiss National Science Foundation, grants from Zurich Lung, grants from Orpha Swiss, personal fees from Actelion SA, Switzerland, personal fees from MSD Switzerland, outside the submitted work.