Catalpol Ameliorates Insulin Sensitivity and Mitochondrial Respiration in Skeletal Muscle of Type-2 Diabetic Mice Through Insulin Signaling Pathway and AMPK/SIRT1/PGC-1α/PPAR-γ Activation.
AMP-Activated Protein Kinase Kinases
Animals
Diabetes Mellitus, Type 2
/ drug therapy
Disease Models, Animal
Humans
Insulin
/ genetics
Insulin Resistance
/ genetics
Iridoid Glucosides
/ pharmacology
Mice, Inbred NOD
/ genetics
Mitochondrial Diseases
Muscle, Skeletal
/ drug effects
PPAR gamma
/ genetics
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
/ genetics
Protein Kinases
/ genetics
Signal Transduction
/ drug effects
Sirtuin 1
/ genetics
catalpol
glucose homeostasis
insulin sensitivity
insulin signaling pathway
mitochondrial respiration
oxygen consumption rate
type-2 diabetes mellitus
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
24 09 2020
24 09 2020
Historique:
received:
24
08
2020
revised:
06
09
2020
accepted:
09
09
2020
entrez:
29
9
2020
pubmed:
30
9
2020
medline:
29
6
2021
Statut:
epublish
Résumé
Catalpol was tested for various disorders including diabetes mellitus. Numerous molecular mechanisms have emerged supporting its biological effects but with little information towards its insulin sensitizing effect. In this study, we have investigated its effect on skeletal muscle mitochondrial respiration and insulin signaling pathway. Type-2 diabetes (T2DM) was induced in male C57BL/6 by a high fat diet (60% Kcal) and streptozotocin (50 mg/kg, i.p.). Diabetic mice were orally administered with catalpol (100 and 200 mg/kg), metformin (200 mg/kg), and saline for four weeks. Fasting blood glucose (FBG), HbA1c, plasma insulin, oral glucose tolerance test (OGTT), insulin tolerance test (ITT), oxygen consumption rate, gene (IRS-1, Akt, PI3k, AMPK, GLUT4, and PGC-1α) and protein (AMPK, GLUT4, and PPAR-γ) expression in muscle were measured. Catalpol (200 mg/kg) significantly (
Identifiants
pubmed: 32987623
pii: biom10101360
doi: 10.3390/biom10101360
pmc: PMC7598587
pii:
doi:
Substances chimiques
Insulin
0
Iridoid Glucosides
0
PPAR gamma
0
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
0
Pparg protein, mouse
0
Ppargc1a protein, mouse
0
catalpol
2415-24-9
Protein Kinases
EC 2.7.-
AMP-Activated Protein Kinase Kinases
EC 2.7.11.3
Sirtuin 1
EC 3.5.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Higher Education, Malaysia
ID : FRGS/1/2015/SKK10/IMU/02/1
Pays : International
Références
Molecules. 2019 Sep 11;24(18):
pubmed: 31514313
Circ Res. 2007 Mar 30;100(6):795-806
pubmed: 17395885
Cell. 1999 Jul 9;98(1):115-24
pubmed: 10412986
J Clin Invest. 2005 Dec;115(12):3587-93
pubmed: 16284649
Yakugaku Zasshi. 1971 May;91(5):593-6
pubmed: 5105149
Diabetes Ther. 2010 Dec;1(2):121-30
pubmed: 22127749
Chin Med. 2016 May 11;11:25
pubmed: 27175212
Circ Res. 2007 Jun 8;100(11):1589-96
pubmed: 17478729
Antioxid Redox Signal. 2007 Mar;9(3):343-53
pubmed: 17184177
J Clin Invest. 1998 Feb 1;101(3):543-8
pubmed: 9449686
Diabetes. 2004 Mar;53(3):542-8
pubmed: 14988236
Diabetes. 2006 Dec;55(12):3309-19
pubmed: 17130474
Circulation. 2005 Nov 15;112(20):3030-2
pubmed: 16286599
Appl Physiol Nutr Metab. 2020 Oct;45(10):1127-1137
pubmed: 32294390
FASEB J. 2002 Dec;16(14):1879-86
pubmed: 12468452
Metabolism. 1998 Jun;47(6):663-8
pubmed: 9627363
J Clin Invest. 2000 Oct;106(7):847-56
pubmed: 11018072
PLoS One. 2017 Aug 29;12(8):e0183978
pubmed: 28850625
Circulation. 2007 Feb 20;115(7):909-17
pubmed: 17261654
Korean J Physiol Pharmacol. 2016 Mar;20(2):153-60
pubmed: 26937211
J Physiol. 2007 Aug 15;583(Pt 1):9-24
pubmed: 17584843
Science. 2003 Feb 7;299(5608):896-9
pubmed: 12574632
Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8466-71
pubmed: 12832613
Diabetes. 2008 Nov;57(11):2943-9
pubmed: 18678616
Nat Prod Res. 2019 Dec 4;:1-5
pubmed: 31797687
Diabetes. 2001 Apr;50(4):824-30
pubmed: 11289048
J Diabetes Res. 2015;2015:973142
pubmed: 26064993
J Biol Chem. 1994 Feb 4;269(5):3568-73
pubmed: 8106400
Biology (Basel). 2019 May 11;8(2):
pubmed: 31083560
Endocr Connect. 2015 Mar;4(1):R1-R15
pubmed: 25385852
Nature. 2001 Sep 13;413(6852):131-8
pubmed: 11557972
J Biol Chem. 2003 Jul 18;278(29):26597-603
pubmed: 12734177
Cell. 1998 Mar 20;92(6):829-39
pubmed: 9529258
J Peripher Nerv Syst. 2013 Dec;18(4):306-15
pubmed: 24147903
Life Sci. 2018 Sep 15;209:313-323
pubmed: 30118770
Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7996-8001
pubmed: 12808136
Clin Endocrinol (Oxf). 1994 May;40(5):611-5
pubmed: 8013142
Diabetes. 2002 Jul;51(7):2005-11
pubmed: 12086926
J Endocrinol. 2017 Sep;234(3):255-267
pubmed: 28611211
J Clin Endocrinol Metab. 1989 Feb;68(2):374-8
pubmed: 2645308
J Nutr. 2006 Aug;136(8):2194-200
pubmed: 16857840
Diabetes. 1999 Jun;48(6):1270-4
pubmed: 10342815
J Biol Chem. 2008 Aug 15;283(33):22464-72
pubmed: 18579525
Diabet Med. 1992 Jun;9(5):432-7
pubmed: 1611830
Metabolism. 2008 Nov;57(11):1584-90
pubmed: 18940398
J Clin Invest. 2006 Mar;116(3):615-22
pubmed: 16511594
Diabetes Care. 1999 Sep;22(9):1462-70
pubmed: 10480510
Diabet Med. 2002 Sep;19(9):708-23
pubmed: 12207806
Lancet. 2009 Jun 27;373(9682):2215-21
pubmed: 19515410
Biochem Biophys Res Commun. 2015 Nov 27;467(4):853-8
pubmed: 26474703
Diabet Med. 2005 Jan;22(1):39-44
pubmed: 15606689
Diabetes. 2006 Dec;55 Suppl 2:S9-S15
pubmed: 17130651
J Biol Chem. 2002 Dec 27;277(52):50230-6
pubmed: 12006582
Biomolecules. 2019 Dec 24;10(1):
pubmed: 31878316
Lancet. 2010 Jun 26;375(9733):2215-22
pubmed: 20609967
Acta Biochim Biophys Sin (Shanghai). 2014 Sep;46(9):738-48
pubmed: 25178463
J Agric Food Chem. 2011 Apr 27;59(8):3747-53
pubmed: 21391677
J Biol Chem. 2012 Jan 13;287(3):1847-60
pubmed: 22117073
Acta Pharmacol Sin. 2020 Jun;41(6):791-799
pubmed: 31937931
Curr Opin Clin Nutr Metab Care. 2018 Jul;21(4):267-272
pubmed: 29847447
Pharmacol Res. 2018 Apr;130:466-480
pubmed: 29284152
Biochim Biophys Acta. 2005 Jun 30;1741(1-2):206-14
pubmed: 15894466
Diabet Med. 2002 Jul;19(7):527-34
pubmed: 12099954
J Biol Chem. 2000 Jan 7;275(1):223-8
pubmed: 10617608