Regulation of Polyomavirus Transcription by Viral and Cellular Factors.
BK Virus
/ genetics
Carcinoma, Merkel Cell
/ pathology
Gene Expression Regulation, Viral
/ genetics
Humans
JC Virus
/ genetics
Latent Infection
/ virology
Leukoencephalopathy, Progressive Multifocal
/ pathology
Merkel cell polyomavirus
/ genetics
Polyomavirus
/ genetics
Polyomavirus Infections
/ pathology
Simian virus 40
/ genetics
Tumor Virus Infections
/ pathology
cell type-specific transcription factors
cis-acting regulatory elements
epigenetic modifications
polyomavirus
transcription
tropism
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
24 09 2020
24 09 2020
Historique:
received:
21
08
2020
revised:
18
09
2020
accepted:
22
09
2020
entrez:
29
9
2020
pubmed:
30
9
2020
medline:
17
2
2021
Statut:
epublish
Résumé
Polyomavirus infection is widespread in the human population. This family of viruses normally maintains latent infection within the host cell but can cause a range of human pathologies, especially in immunocompromised individuals. Among several known pathogenic human polyomaviruses, JC polyomavirus (JCPyV) has the potential to cause the demyelinating disease progressive multifocal leukoencephalopathy (PML); BK polyomavirus (BKPyV) can cause nephropathy in kidney transplant recipients, and Merkel cell polyomavirus (MCPyV) is associated with a highly aggressive form of skin cancer, Merkel cell carcinoma (MCC). While the mechanisms by which these viruses give rise to the relevant diseases are not well understood, it is clear that the control of gene expression in each polyomavirus plays an important role in determining the infectious tropism of the virus as well as their potential to promote disease progression. In this review, we discuss the mechanisms governing the transcriptional regulation of these pathogenic human polyomaviruses in addition to the best-studied simian vacuolating virus 40 (SV40). We highlight the roles of viral
Identifiants
pubmed: 32987952
pii: v12101072
doi: 10.3390/v12101072
pmc: PMC7601649
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAMS NIH HHS
ID : R21 AR074073
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI045008
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA187718
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016520
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI149761
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA115299
Pays : United States
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