Intrauterine exposure to diabetes and risk of cardiovascular disease in adolescence and early adulthood: a population-based birth cohort study.
Adolescent
Adult
Cardiovascular Diseases
/ epidemiology
Child
Cohort Studies
Diabetes Mellitus, Type 2
/ epidemiology
Diabetes, Gestational
/ epidemiology
Female
Follow-Up Studies
Humans
Male
Manitoba
/ epidemiology
Pregnancy
Pregnancy in Diabetics
/ epidemiology
Prenatal Exposure Delayed Effects
/ epidemiology
Registries
Young Adult
Journal
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
ISSN: 1488-2329
Titre abrégé: CMAJ
Pays: Canada
ID NLM: 9711805
Informations de publication
Date de publication:
28 Sep 2020
28 Sep 2020
Historique:
accepted:
07
05
2020
entrez:
29
9
2020
pubmed:
30
9
2020
medline:
25
5
2021
Statut:
ppublish
Résumé
It is unclear whether intrauterine exposure to maternal diabetes is associated with risk factors for cardiovascular disease and related end points in adulthood. We examined this potential association in a population-based birth cohort followed up to age 35 years. We performed a cohort study of offspring born between 1979 and 2005 ( The cohort provided 3 628 576 person-years of data (mean age at latest follow-up 20.5 [standard deviation 6.4] years, 49.3% female); 2765 (0.9%) of the offspring experienced a cardiovascular disease end point, and 12 673 (4.3%) experienced a cardiovascular disease risk factor. After propensity score matching, the hazard for cardiovascular disease end points was elevated in offspring exposed to gestational diabetes (adjusted hazard ratio [HR] 1.42, 95% confidence interval [CI] 1.12-1.79) but not type 2 diabetes (adjusted HR 1.40, 95% CI 0.98-2.01). A similar association was observed for cardiovascular disease risk factors (gestational diabetes: adjusted HR 1.92, 95% CI 1.75-2.11; type 2 diabetes: adjusted HR 3.40, 95% CI 3.00-3.85). Intrauterine exposure to maternal diabetes was associated with higher morbidity and risk related to cardiovascular disease among offspring up to 35 years of age.
Sections du résumé
BACKGROUND
BACKGROUND
It is unclear whether intrauterine exposure to maternal diabetes is associated with risk factors for cardiovascular disease and related end points in adulthood. We examined this potential association in a population-based birth cohort followed up to age 35 years.
METHODS
METHODS
We performed a cohort study of offspring born between 1979 and 2005 (
RESULTS
RESULTS
The cohort provided 3 628 576 person-years of data (mean age at latest follow-up 20.5 [standard deviation 6.4] years, 49.3% female); 2765 (0.9%) of the offspring experienced a cardiovascular disease end point, and 12 673 (4.3%) experienced a cardiovascular disease risk factor. After propensity score matching, the hazard for cardiovascular disease end points was elevated in offspring exposed to gestational diabetes (adjusted hazard ratio [HR] 1.42, 95% confidence interval [CI] 1.12-1.79) but not type 2 diabetes (adjusted HR 1.40, 95% CI 0.98-2.01). A similar association was observed for cardiovascular disease risk factors (gestational diabetes: adjusted HR 1.92, 95% CI 1.75-2.11; type 2 diabetes: adjusted HR 3.40, 95% CI 3.00-3.85).
INTERPRETATION
CONCLUSIONS
Intrauterine exposure to maternal diabetes was associated with higher morbidity and risk related to cardiovascular disease among offspring up to 35 years of age.
Identifiants
pubmed: 32989023
pii: 192/39/E1104
doi: 10.1503/cmaj.190797
pmc: PMC7532013
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
E1104-E1113Informations de copyright
© 2020 Joule Inc. or its licensors.
Déclaration de conflit d'intérêts
Competing interests: Brandy Wicklow is currently the site principal investigator for a Boehringer Ingelheim study unrelated to the current study content. No other competing interests were declared.
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