MAIT cell activation and dynamics associated with COVID-19 disease severity.
Adult
Aged
Antigens, CD
/ metabolism
Antigens, Differentiation, T-Lymphocyte
/ metabolism
Betacoronavirus
/ immunology
COVID-19
Coronavirus Infections
/ immunology
Female
Humans
Immunity, Innate
/ immunology
Inflammation
/ immunology
Interleukin-17
/ metabolism
Lectins, C-Type
/ metabolism
Lymphocyte Activation
/ immunology
Male
Middle Aged
Mucosal-Associated Invariant T Cells
/ immunology
Pandemics
Pneumonia, Viral
/ immunology
Receptors, CXCR3
/ metabolism
SARS-CoV-2
Young Adult
Journal
Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624
Informations de publication
Date de publication:
28 09 2020
28 09 2020
Historique:
received:
04
08
2020
accepted:
22
09
2020
entrez:
29
9
2020
pubmed:
30
9
2020
medline:
21
10
2020
Statut:
ppublish
Résumé
Severe COVID-19 is characterized by excessive inflammation of the lower airways. The balance of protective versus pathological immune responses in COVID-19 is incompletely understood. Mucosa-associated invariant T (MAIT) cells are antimicrobial T cells that recognize bacterial metabolites, and can also function as innate-like sensors and mediators of antiviral responses. Here, we investigated the MAIT cell compartment in COVID-19 patients with moderate and severe disease, as well as in convalescence. We show profound and preferential decline in MAIT cells in the circulation of patients with active disease paired with strong activation. Furthermore, transcriptomic analyses indicated significant MAIT cell enrichment and pro-inflammatory IL-17A bias in the airways. Unsupervised analysis identified MAIT cell CD69
Identifiants
pubmed: 32989174
pii: 5/51/eabe1670
doi: 10.1126/sciimmunol.abe1670
pmc: PMC7857393
pii:
doi:
Substances chimiques
Antigens, CD
0
Antigens, Differentiation, T-Lymphocyte
0
CD69 antigen
0
CXCR3 protein, human
0
IL17A protein, human
0
Interleukin-17
0
Lectins, C-Type
0
Receptors, CXCR3
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Investigateurs
John Tyler Sandberg
(JT)
Helena Bergsten
(H)
Niklas K Björkström
(NK)
Susanna Brighenti
(S)
Marcus Buggert
(M)
Marta Butrym
(M)
Benedict J Chambers
(BJ)
Puran Chen
(P)
Martin Cornillet
(M)
Angelica Cuapio
(A)
Isabel Diaz Lozano
(I)
Majda Dzidic
(M)
Johanna Emgård
(J)
Malin Flodström-Tullberg
(M)
Jean-Baptiste Gorin
(JB)
Sara Gredmark-Russ
(S)
Alvaro Haroun-Izquierdo
(A)
Laura Hertwig
(L)
Sadaf Kalsum
(S)
Jonas Klingström
(J)
Efthymia Kokkinou
(E)
Egle Kvedaraite
(E)
Hans-Gustaf Ljunggren
(HG)
Magdalini Lourda
(M)
Kimia T Maleki
(KT)
Karl-Johan Malmberg
(KJ)
Jakob Michaëlsson
(J)
Jenny Mjösberg
(J)
Kirsten Moll
(K)
Jagadeeswara Rao Muvva
(JR)
Anna Norrby-Teglund
(A)
Laura M Palma Medina
(LM)
Tiphaine Parrot
(T)
Lena Radler
(L)
Emma Ringqvist
(E)
Johan K Sandberg
(JK)
Takuya Sekine
(T)
Tea Soini
(T)
Mattias Svensson
(M)
Janne Tynell
(J)
Andreas Von Kries
(A)
David Wullimann
(D)
André Perez-Potti
(A)
Olga Rivera-Ballesteros
(O)
Christopher Maucourant
(C)
Renata Varnaite
(R)
Mira Akber
(M)
Lena Berglin
(L)
Demi Brownlie
(D)
Marco Giulio Loreti
(MG)
Ebba Sohlberg
(E)
Tobias Kammann
(T)
Elisabeth Henriksson
(E)
Nicole Marquardt
(N)
Kristoffer Strålin
(K)
Soo Aleman
(S)
Anders Sönnerborg
(A)
Lena Dillner
(L)
Anna Färnert
(A)
Hedvig Glans
(H)
Pontus Nauclér
(P)
Olav Rooyackers
(O)
Johan Mårtensson
(J)
Lars I Eriksson
(LI)
Björn P Persson
(BP)
Jonathan Grip
(J)
Christian Unge
(C)
Informations de copyright
Copyright © 2020, American Association for the Advancement of Science.
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