Prognostic Utility of the Glasgow Prognostic Score for the Long-Term Outcomes After Liver Resection for Intrahepatic Cholangiocarcinoma: A Multi-institutional Study.
Journal
World journal of surgery
ISSN: 1432-2323
Titre abrégé: World J Surg
Pays: United States
ID NLM: 7704052
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
accepted:
08
09
2020
pubmed:
30
9
2020
medline:
9
6
2021
entrez:
29
9
2020
Statut:
ppublish
Résumé
The usefulness of the modified Glasgow prognostic score (GPS) as a prognostic tool remains unclear for patients undergoing curative surgery for intrahepatic cholangiocarcinoma (ICC). Therefore, this study investigated the prognostic usefulness of the GPS for patients who underwent ICC surgery. All ICC patients who had a curative-intent hepatectomy at 17 institutions between 2000 and 2016 were included. The correlation was assessed between the preoperative GPS and the baseline characteristics of the patients, histopathological parameters, surgical parameters, and the postresection overall survival (OS). There were 273 patients who met the eligibility criteria between the years 2000 and 2016. The postoperative OS rates at 1, 3, and 5 years were 83.8%, 56.3%, and 41.5%, respectively (median OS, 47.7 months). A multivariate analysis revealed the factors that were associated with a worse OS, which included an increased GPS (hazard ratio = 1.62; 95% confidence interval [CI]: 1.01-2.53; P = 0.03), an elevated carcinoembryonic antigen level (hazard ratio = 1.60; 95% CI: 1.06-2.41; P = 0.02), an elevated carbohydrate antigen 19-9 level (hazard ratio = 1.55; 95% CI: 1.05-2.30; P = 0.03), undifferentiated carcinoma (hazard ratio = 2.41; 95% CI: 1.56-3.67; P < 0.01), and positive metastasis to the lymph nodes (hazard ratio = 2.54; 95% CI: 1.76-3.67; P < 0.01). In ICC patients after a hepatectomy, an elevated GPS was associated with poorer OS, even if the tumour factors that affected GPS were eliminated by propensity-score matching. Preoperative GPS can be useful to predict the postoperative outcomes of ICC patients. Therefore, this relatively simple and inexpensive scoring system can be utilized to further refine patient stratification as well as to predict survival.
Identifiants
pubmed: 32989578
doi: 10.1007/s00268-020-05797-4
pii: 10.1007/s00268-020-05797-4
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
279-290Subventions
Organisme : Japan Society for the Promotion of Science
ID : 19K09217
Références
Bray F, Ferlay J, Soerjomataram I et al (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68:394–424
Alpini G, Prall R, LaRusso NF (2001) The pathobiology of biliary epithelia. In: Arias IM, Boyer JL, Chisari FV, et al. (eds) The liver biology and pathobiology, 4th edn. Lippincott Williams & Wilkins, Philadelphia
Satriano L, Lewinska M, Rodrigues PM et al (2019) Metabolic rearrangements in primary liver cancers: cause and consequences. Nat Rev Gastroenterol Hepatol 16:748–766
doi: 10.1038/s41575-019-0217-8
Okabayashi T, Yamamoto J, Kosuge T et al (2001) A new staging system for mass-forming intrahepatic cholangiocarcinoma: analysis of preoperative and postoperative variables. Cancer 92:2374–2383
doi: 10.1002/1097-0142(20011101)92:9<2374::AID-CNCR1585>3.0.CO;2-L
Schnitzbauer AA, Eberhard J, Bartsch F et al (2019) The MEGNA score and preoperative anemia are major prognostic factors after resection in the German intrahepatic cholangiocarcinoma cohort. Ann Surg Oncol. https://doi.org/10.1245/s10434-019-07968-7
doi: 10.1245/s10434-019-07968-7
pubmed: 31646454
Wang Y, Li J, Xia Y et al (2013) Prognostic nomogram for intrahepatic cholangiocarcinoma after partial hepatectomy. J Clin Oncol 31:1188–1195
doi: 10.1200/JCO.2012.41.5984
Massarweh NN, El-Serag HB (2017) Epidemiology of hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Cancer Control 24:1073274817729245
doi: 10.1177/1073274817729245
Sharaiha RZ, Halazun KJ, Mirza F et al (2011) Elevated preoperative neutrophil: lymphocyte ratio as a predictor of postoperative disease recurrence in esophageal cancer. Ann Surg Oncol 18:3362–3369
doi: 10.1245/s10434-011-1754-8
Chan JC, Chan DL, Diakos CI et al (2017) The lymphocyte-to-monocyte ratio is a superior predictor of overall survival in comparison to established biomarkers of resectable colorectal cancer. Ann Surg 265:539–546
doi: 10.1097/SLA.0000000000001743
Mano Y, Shirabe K, Yamashita Y et al (2013) Preoperative neutrophil-to-lymphocyte ratio is a predictor of survival after hepatectomy for hepatocellular carcinoma: a retrospective analysis. Ann Surg 258:301–305
doi: 10.1097/SLA.0b013e318297ad6b
Okabayashi T, Shima Y, Sumiyoshi T et al (2018) A Novel physiobiological parameter-based grading system for resectable pancreatic cancer. Ann Surg Oncol 25:1889–1895
doi: 10.1245/s10434-018-6485-7
Ishii Y, Sasaki T, Serikawa M et al (2013) Elevated expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in primary sclerosing cholangitis: iotamplications for cholangiocarcinogenesis. Int J Oncol 43:1073–1079
doi: 10.3892/ijo.2013.2038
Lin G, Liu Y, Li S et al (2016) Elevated neutrophil-to-lymphocyte ratio is an independent poor prognostic factor in patients with intrahepatic cholangiocarcinoma. Oncotarget 7:50963–50971
doi: 10.18632/oncotarget.7680
Ohira M, Yoshizumi T, Yugawa K et al (2019) Association of inflammatory biomarkers with long-term outcomes after curative surgery for mass-forming intrahepatic cholangiocarcinoma. Surg Today. https://doi.org/10.1007/s00595-019-01905-7
doi: 10.1007/s00595-019-01905-7
pubmed: 31667580
McMillan DC (2008) An inflammation-based prognostic score and its role in the nutrition-based management of patients with cancer. Proc Nutr Soc 67:257–262
doi: 10.1017/S0029665108007131
Dolan RD, Almasaudi AS, Dieu LB et al (2019) The relationship between computed tomography-derived body composition, systemic inflammatory response, and survival in patients undergoing surgery for colorectal cancer. J Cachexia Sarcopenia Muscle 10:111–122
doi: 10.1002/jcsm.12357
Reeh M, Ghadban T, Uzunoglu FG et al (2017) Hamburg-Glasgow classification: preoperative staging by combination of disseminated tumour load and systemic inflammation in oesophageal carcinoma. Br J Cancer 117:612–618
doi: 10.1038/bjc.2017.219
Pan QX, Su ZJ, Zhang JH et al (2017) Glasgow prognostic score predicts prognosis of intrahepatic cholangiocarcinoma. Mol Clin Oncol 6:566–574
doi: 10.3892/mco.2017.1166
Antonioli L, Blandizzi C, Pacher P et al (2013) Immunity, inflammation and cancer: a leading role for adenosine. Nat Rev Cancer 13:842–857
doi: 10.1038/nrc3613
Mantovani A, Allavena P, Sica A et al (2008) Cancer-related inflammation. Nature 454:436–444
doi: 10.1038/nature07205
Rogers PC (2014) Nutritional status as a prognostic indicator for pediatric malignancies. J Clin Oncol 32:1293–1294
doi: 10.1200/JCO.2014.55.0616
Lamarca A, Barriuso J, McNamara MG et al (2018) Biliary tract cancer: state of the art and potential role of DNA damage repair. Cancer Treat Rev 70:168–177
doi: 10.1016/j.ctrv.2018.09.002
Primrose JN, Fox RP, Palmer DH,: BILCAP study group, et al (2019) Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study. Lancet Oncol 20:663–673
doi: 10.1016/S1470-2045(18)30915-X
Bridgewater J, Galle PR, Khan SA et al (2014) Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma. J Hepatol 60:1268–1289
doi: 10.1016/j.jhep.2014.01.021