Toddler neurodevelopment is associated with ganglioside intake but not serum ganglioside.
Journal
Asia Pacific journal of clinical nutrition
ISSN: 1440-6047
Titre abrégé: Asia Pac J Clin Nutr
Pays: China
ID NLM: 9440304
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
29
9
2020
pubmed:
30
9
2020
medline:
2
7
2021
Statut:
ppublish
Résumé
Gangliosides (GAs) are important components of neural tissue and cell membrane. This study aims to investigate the association between toddlers' neurodevelopment, dietary GA intake, and serum GA concentration. A cross-sectional study was conducted in Beijing and Xuchang, Henan Province in China. 110 eligible healthy toddlers aged 24-48 months were recruited. Food frequency questionnaire (FFQ) and 24-h dietary recall were used to collect dietary information. Blood serum samples obtained from participants were used to perform GA composition analysis with high-performance liquid chromatographymass spectrometry (HPLC-MS). The neurodevelopment level was assessed with the Gesell Developmental Scale (GDS). Dietary ganglioside GD3, total GA, and seafood intake were identified to be associated with the gross motor developmental quotient (DQ). An inverse association was revealed between the fine motor DQ and fruit intake. No correlation was detected between serum GA concentration and DQ. Dietary GA intake but not serum GA concentration is associated with neurodevelopment. Further prospective studies are needed to probe the relationships between the recommended dietary GA intake and toddlers.
Sections du résumé
BACKGROUND AND OBJECTIVES
OBJECTIVE
Gangliosides (GAs) are important components of neural tissue and cell membrane. This study aims to investigate the association between toddlers' neurodevelopment, dietary GA intake, and serum GA concentration.
METHODS AND STUDY DESIGN
METHODS
A cross-sectional study was conducted in Beijing and Xuchang, Henan Province in China. 110 eligible healthy toddlers aged 24-48 months were recruited. Food frequency questionnaire (FFQ) and 24-h dietary recall were used to collect dietary information. Blood serum samples obtained from participants were used to perform GA composition analysis with high-performance liquid chromatographymass spectrometry (HPLC-MS). The neurodevelopment level was assessed with the Gesell Developmental Scale (GDS).
RESULTS
RESULTS
Dietary ganglioside GD3, total GA, and seafood intake were identified to be associated with the gross motor developmental quotient (DQ). An inverse association was revealed between the fine motor DQ and fruit intake. No correlation was detected between serum GA concentration and DQ.
CONCLUSIONS
CONCLUSIONS
Dietary GA intake but not serum GA concentration is associated with neurodevelopment. Further prospective studies are needed to probe the relationships between the recommended dietary GA intake and toddlers.
Identifiants
pubmed: 32990619
doi: 10.6133/apjcn.202009_29(3).0018
doi:
Substances chimiques
Gangliosides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM