The exploration of Parkinson's disease: a multi-modal data analysis of resting functional magnetic resonance imaging and gene data.
Clustering evolution random forest
Multi-modal data fusion
Parkinson’s disease
RfMRI
SNP
Journal
Brain imaging and behavior
ISSN: 1931-7565
Titre abrégé: Brain Imaging Behav
Pays: United States
ID NLM: 101300405
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
accepted:
31
08
2020
pubmed:
30
9
2020
medline:
7
9
2021
entrez:
29
9
2020
Statut:
ppublish
Résumé
Parkinson's disease (PD) is the most universal chronic degenerative neurological dyskinesia and an important threat to elderly health. At present, the researches of PD are mainly based on single-modal data analysis, while the fusion research of multi-modal data may provide more meaningful information in the aspect of comprehending the pathogenesis of PD. In this paper, 104 samples having resting functional magnetic resonance imaging (rfMRI) and gene data are from Parkinson's Progression Markers Initiative (PPMI) and Alzheimer's Disease Neuroimaging Initiative (ADNI) database to predict pathological brain areas and risk genes related to PD. In the experiment, Pearson correlation analysis is adopted to conduct fusion analysis from the data of genes and brain areas as multi-modal sample characteristics, and the clustering evolution random forest (CERF) method is applied to detect the discriminative genes and brain areas. The experimental results indicate that compared with several existing advanced methods, the CERF method can further improve the diagnosis of PD and healthy control, and can achieve a significant effect. More importantly, we find that there are some interesting associations between brain areas and genes in PD patients. Based on these associations, we notice that PD-related brain areas include angular gyrus, thalamus, posterior cingulate gyrus and paracentral lobule, and risk genes mainly include C6orf10, HLA-DPB1 and HLA-DOA. These discoveries have a significant contribution to the early prevention and clinical treatments of PD.
Identifiants
pubmed: 32990896
doi: 10.1007/s11682-020-00392-6
pii: 10.1007/s11682-020-00392-6
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1986-1996Subventions
Organisme : Hunan Provincial Education Department
ID : 2019JGYB091
Organisme : Hunan Provincial Science and Technology Department
ID : 2018TP1018
Organisme : National Natural Science Foundation of China
ID : 61502167
Informations de copyright
© 2020. Springer Science+Business Media, LLC, part of Springer Nature.
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