Knowing what you need to know in advance: The neural processes underpinning flexible semantic retrieval of thematic and taxonomic relations.
Control
Executive
Hub and spoke model
Left inferior frontal gyrus
Semantic cognition
Top-down
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
01 01 2021
01 01 2021
Historique:
received:
05
06
2020
revised:
22
08
2020
accepted:
22
09
2020
pubmed:
30
9
2020
medline:
9
3
2021
entrez:
29
9
2020
Statut:
ppublish
Résumé
Semantic retrieval is flexible, allowing us to focus on subsets of features and associations that are relevant to the current task or context: for example, we use taxonomic relations to locate items in the supermarket (carrots are a vegetable), but thematic associations to decide which tools we need when cooking (carrot goes with peeler). We used fMRI to investigate the neural basis of this form of semantic flexibility; in particular, we asked how retrieval unfolds differently when participants have advanced knowledge of the type of link to retrieve between concepts (taxonomic or thematic). Participants performed a semantic relatedness judgement task: on half the trials, they were cued to search for a taxonomic or thematic link, while on the remaining trials, they judged relatedness without knowing which type of semantic relationship would be relevant. Left inferior frontal gyrus showed greater activation when participants knew the trial type in advance. An overlapping region showed a stronger response when the semantic relationship between the items was weaker, suggesting this structure supports both top-down and bottom-up forms of semantic control. Multivariate pattern analysis further revealed that the neural response in left inferior frontal gyrus reflects goal information related to different conceptual relationships. Top-down control specifically modulated the response in visual cortex: when the goal was unknown, there was greater deactivation to the first word, and greater activation to the second word. We conclude that top-down control of semantic retrieval is primarily achieved through the gating of task-relevant 'spoke' regions.
Identifiants
pubmed: 32992002
pii: S1053-8119(20)30890-9
doi: 10.1016/j.neuroimage.2020.117405
pmc: PMC7779371
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
117405Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors have declared that no competing interests exist.
Références
Neuron. 2002 Aug 15;35(4):803-12
pubmed: 12194878
J Neurosci. 2012 Nov 7;32(45):15728-36
pubmed: 23136412
Proc Natl Acad Sci U S A. 2011 May 17;108(20):8520-4
pubmed: 21540329
Cogn Affect Behav Neurosci. 2006 Sep;6(3):201-13
pubmed: 17243356
Elife. 2018 Nov 06;7:
pubmed: 30394873
Mem Cognit. 2019 Nov;47(8):1567-1581
pubmed: 31215011
J Exp Psychol Learn Mem Cogn. 1993 Nov;19(6):1254-76
pubmed: 8270887
J Cogn Neurosci. 2013 Oct;25(10):1723-35
pubmed: 23662861
J Neurosci. 2015 Nov 18;35(46):15230-9
pubmed: 26586812
Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):11078-83
pubmed: 26283350
Neuropsychologia. 2017 Sep;104:113-125
pubmed: 28803767
Neuropsychologia. 2015 Sep;76:92-107
pubmed: 25726898
Neuroimage. 2011 Jan 15;54(2):1465-75
pubmed: 20884358
Nature. 1994 Nov 17;372(6503):260-3
pubmed: 7969469
Cereb Cortex. 2005 Nov;15(11):1768-78
pubmed: 15728740
Neuroimage. 2009 Jan 1;44(1):83-98
pubmed: 18501637
Neuroimage. 2009 Feb 1;44(3):893-905
pubmed: 18976716
Neuroimage. 2004 May;22(1):164-70
pubmed: 15110006
Neuroimage. 2009 Feb 1;44(3):1152-62
pubmed: 18977304
J Exp Psychol Gen. 2001 Mar;130(1):3-28
pubmed: 11293459
Child Dev. 1991 Aug;62(4):767-81
pubmed: 1935342
Neuroimage. 2008 Jun;41(2):286-301
pubmed: 18407525
Neuroimage. 2006 Dec;33(4):1194-206
pubmed: 17023179
J Cogn Neurosci. 2012 Jan;24(1):133-47
pubmed: 21861680
Cereb Cortex. 2009 Dec;19(12):2767-96
pubmed: 19329570
Cereb Cortex. 2011 May;21(5):1066-75
pubmed: 20851853
Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3863-8
pubmed: 16537458
J Cogn Neurosci. 2010 Jun;22(6):1083-94
pubmed: 19583477
J Neurosci. 2011 Oct 12;31(41):14592-9
pubmed: 21994375
Cortex. 2013 Mar;49(3):611-25
pubmed: 23260615
Psychon Bull Rev. 2014 Jun;21(3):645-51
pubmed: 24186270
Neuroimage. 2007 Aug 1;37(1):90-101
pubmed: 17560126
J Cogn Neurosci. 2019 Nov;31(11):1599-1616
pubmed: 30156502
Cereb Cortex. 2012 Aug;22(8):1761-73
pubmed: 21968566
Neuropsychologia. 2019 Aug;131:294-305
pubmed: 31163176
Neuroimage. 2016 Aug 15;137:165-177
pubmed: 27236083
J Neurosci. 2014 Jul 30;34(31):10347-60
pubmed: 25080595
J Speech Lang Hear Res. 2007 Feb;50(1):161-76
pubmed: 17344557
Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14792-7
pubmed: 9405692
Cereb Cortex. 2005 May;15(5):616-27
pubmed: 15342435
Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16616-21
pubmed: 24062451
Cereb Cortex. 2015 Oct;25(10):3547-60
pubmed: 25205661
Front Neuroinform. 2015 Apr 10;9:8
pubmed: 25914639
Neuroimage. 2016 Nov 1;141:366-377
pubmed: 27485753
Neuroimage. 2011 Sep 15;58(2):362-80
pubmed: 21718787
Neuroimage. 2019 Oct 1;199:114-126
pubmed: 31132452
Neuroimage. 2018 Aug 1;176:518-527
pubmed: 29733956
Nat Rev Neurosci. 2007 Dec;8(12):976-87
pubmed: 18026167
Front Syst Neurosci. 2011 Feb 10;5:1
pubmed: 21347218
Trends Neurosci. 1992 Jan;15(1):20-5
pubmed: 1374953
Trends Cogn Sci. 2014 Feb;18(2):90-8
pubmed: 24373885
J Cogn Neurosci. 2011 Sep;23(9):2544-57
pubmed: 21265605
Neuroreport. 1998 Mar 30;9(5):803-8
pubmed: 9579669
Philos Trans R Soc Lond B Biol Sci. 2018 Aug 5;373(1752):
pubmed: 29915004
Sci Rep. 2018 Feb 14;8(1):3047
pubmed: 29445098
Cereb Cortex. 2015 Nov;25(11):4319-33
pubmed: 25636912
Brain Lang. 2016 Aug;159:45-59
pubmed: 27289210
Neuroimage. 2004 Aug;22(4):1819-25
pubmed: 15275938
Neuroimage. 2004 Nov;23(3):975-82
pubmed: 15528098
Cereb Cortex. 2010 Nov;20(11):2636-46
pubmed: 20154013
Neuron. 2005 Sep 15;47(6):907-18
pubmed: 16157284
Neuroimage. 2016 Dec;143:128-140
pubmed: 27592809
Neuron. 2002 Aug 15;35(4):625-41
pubmed: 12194864
Nat Rev Neurosci. 2017 Jan;18(1):42-55
pubmed: 27881854
Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12574-12579
pubmed: 27791099
Netw Neurosci. 2020 Jul 01;4(3):637-657
pubmed: 32885119
Cogn Neuropsychol. 2003 May 1;20(3):525-40
pubmed: 20957583
J Neurosci. 1995 Sep;15(9):5870-8
pubmed: 7666172
J Cogn Neurosci. 2010 Jul;22(7):1597-613
pubmed: 19580383
Cognition. 2001 Oct;81(3):B77-86
pubmed: 11483172
Neuropsychologia. 2007 Oct 1;45(13):2883-901
pubmed: 17675110
Brain Connect. 2012;2(3):125-41
pubmed: 22642651
Cortex. 2019 Nov;120:308-325
pubmed: 31394366
J Neurophysiol. 2017 Aug 1;118(2):703-716
pubmed: 28404826
Neuroimage. 2001 Dec;14(6):1370-86
pubmed: 11707093
Neuropsychologia. 2008;46(8):2109-21
pubmed: 18420234
J Neurosci. 2006 May 3;26(18):4917-21
pubmed: 16672666
J Neurosci. 2014 Apr 2;34(14):4766-75
pubmed: 24695697
Cereb Cortex. 2015 Nov;25(11):4374-91
pubmed: 25771223
Neuroimage. 2017 Feb 15;147:19-31
pubmed: 27908787
J Exp Psychol Learn Mem Cogn. 2011 Jan;37(1):149-61
pubmed: 20854006
Brain. 2012 Dec;135(Pt 12):3770-80
pubmed: 23250888
Psychol Sci. 2010 Sep;21(9):1215-9
pubmed: 20639402
Cortex. 2018 Nov;108:127-143
pubmed: 30172096
J Neurosci. 2010 Nov 17;30(46):15450-6
pubmed: 21084601
Cereb Cortex. 2005 Nov;15(11):1723-35
pubmed: 15728742
Neuroimage. 2002 Oct;17(2):825-41
pubmed: 12377157
J Cogn Neurosci. 2009 Mar;21(3):489-510
pubmed: 18510452
J Neurosci. 2016 Jun 8;36(23):6147-55
pubmed: 27277793
Neuropsychologia. 2016 Dec;93(Pt A):40-52
pubmed: 27650816
Cereb Cortex. 2016 Sep;26(9):3838-50
pubmed: 26286919
Neuropsychologia. 2015 Feb;68:176-89
pubmed: 25582406
Brain Lang. 2002 Aug;82(2):179-99
pubmed: 12096875
Cortex. 2016 May;78:174-194
pubmed: 27085513
Psychol Sci. 2013 Jun;24(6):909-19
pubmed: 23633520
Behav Res Methods. 2005 Feb;37(1):65-70
pubmed: 16097345
J Exp Psychol Gen. 2013 Feb;142(1):131-142
pubmed: 22642711
Neuroimage. 2012 Jan 16;59(2):1420-8
pubmed: 21889994
Neuron. 2001 Aug 2;31(2):329-38
pubmed: 11502262
Sci Rep. 2017 Jul 18;7(1):5677
pubmed: 28720781
Curr Biol. 2014 Jun 2;24(11):1256-62
pubmed: 24856208
Cogn Neuropsychol. 2016 May-Jun;33(3-4):175-90
pubmed: 27686110
Sci Rep. 2018 May 25;8(1):8145
pubmed: 29802344
Cortex. 2018 Jun;103:100-116
pubmed: 29604611
PLoS One. 2017 Jan 11;12(1):e0169269
pubmed: 28076421
Neuropsychologia. 1999 Jun;37(6):671-6
pubmed: 10390028
Mem Cognit. 2018 Feb;46(2):191-203
pubmed: 28900903
J Cogn Neurosci. 2012 Aug;24(8):1766-78
pubmed: 22621260
J Cogn Neurosci. 2013 Nov;25(11):1824-50
pubmed: 23859646
Behav Brain Res. 2010 Oct 15;212(2):121-32
pubmed: 20385169
Brain. 1998 Jan;121 ( Pt 1):77-89
pubmed: 9549489
Neuropsychologia. 2008 Jan 31;46(2):649-58
pubmed: 17961610
Neuroinformatics. 2009 Spring;7(1):37-53
pubmed: 19184561
Curr Biol. 2013 Nov 18;23(22):2268-2272
pubmed: 24184103
Brain Res. 2009 May 13;1270:78-87
pubmed: 19306848
Soc Cogn Affect Neurosci. 2015 Mar;10(3):318-26
pubmed: 24795444
Neuropsychologia. 2013 Apr;51(5):789-801
pubmed: 23395830
Neuroimage. 2017 Sep;158:1-11
pubmed: 28655631
Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9318-9323
pubmed: 30150393
J Neurophysiol. 2011 Sep;106(3):1125-65
pubmed: 21653723
Cognition. 2011 Mar;118(3):359-76
pubmed: 21147480