Clinical Characteristics of Stroke with COVID-19: A Systematic Review and Meta-Analysis.
COVID-19
Meta-analysis
SARS-CoV2
Systematic review
stroke
Journal
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
ISSN: 1532-8511
Titre abrégé: J Stroke Cerebrovasc Dis
Pays: United States
ID NLM: 9111633
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
04
08
2020
revised:
18
08
2020
accepted:
24
08
2020
pubmed:
30
9
2020
medline:
15
12
2020
entrez:
29
9
2020
Statut:
ppublish
Résumé
The coronavirus disease 2019 (COVID-19) potentially increases the risk of thromboembolism and stroke. Numerous case reports and retrospective cohort studies have been published with mixed characteristics of COVID-19 patients with stroke regarding age, comorbidities, treatment, and outcome. We aimed to depict the frequency and clinical characteristics of COVID-19 patients with stroke. PubMed and EMBASE were searched on June 10, 2020, to investigate COVID-19 and stroke through retrospective cross-sectional studies, case series/reports according to PRISMA guidelines. Study-specific estimates were combined using one-group meta-analysis in a random-effects model. 10 retrospective cohort studies and 16 case series/reports were identified including 183 patients with COVID-19 and stroke. The frequency of detected stroke in hospitalized COVID-19 patients was 1.1% ([95% confidential interval (CI)]: [0.6-1.6], I This systematic review assessed the frequency and clinical characteristics of stroke in COVID-19 patients. The frequency of detected stroke in hospitalized COVID-19 patients was 1.1% and associated with older age and stroke risk factors. Frequent cryptogenic stroke and elevated d-dimer level support increased risk of thromboembolism in COVID-19 associated with high mortality. Further study is needed to elucidate the pathophysiology and prognosis of stroke in COVID-19 to achieve most effective care for this population.
Sections du résumé
BACKGROUND
BACKGROUND
The coronavirus disease 2019 (COVID-19) potentially increases the risk of thromboembolism and stroke. Numerous case reports and retrospective cohort studies have been published with mixed characteristics of COVID-19 patients with stroke regarding age, comorbidities, treatment, and outcome. We aimed to depict the frequency and clinical characteristics of COVID-19 patients with stroke.
METHODS
METHODS
PubMed and EMBASE were searched on June 10, 2020, to investigate COVID-19 and stroke through retrospective cross-sectional studies, case series/reports according to PRISMA guidelines. Study-specific estimates were combined using one-group meta-analysis in a random-effects model.
RESULTS
RESULTS
10 retrospective cohort studies and 16 case series/reports were identified including 183 patients with COVID-19 and stroke. The frequency of detected stroke in hospitalized COVID-19 patients was 1.1% ([95% confidential interval (CI)]: [0.6-1.6], I
CONCLUSIONS
CONCLUSIONS
This systematic review assessed the frequency and clinical characteristics of stroke in COVID-19 patients. The frequency of detected stroke in hospitalized COVID-19 patients was 1.1% and associated with older age and stroke risk factors. Frequent cryptogenic stroke and elevated d-dimer level support increased risk of thromboembolism in COVID-19 associated with high mortality. Further study is needed to elucidate the pathophysiology and prognosis of stroke in COVID-19 to achieve most effective care for this population.
Identifiants
pubmed: 32992199
pii: S1052-3057(20)30706-0
doi: 10.1016/j.jstrokecerebrovasdis.2020.105288
pmc: PMC7456266
pii:
doi:
Substances chimiques
Biomarkers
0
Fibrin Fibrinogen Degradation Products
0
fibrin fragment D
0
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
105288Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest There is no conflict of interest of this study.
Références
Medicine (Baltimore). 2018 Oct;97(43):e12622
pubmed: 30412062
PLoS One. 2013;8(2):e57121
pubmed: 23468921
Circ Res. 2020 Jul 31;127(4):571-587
pubmed: 32586214
Clin Chem Lab Med. 2014 May;52(5):621-8
pubmed: 24152904
Stroke. 2020 Jul;51(7):2002-2011
pubmed: 32432996
Thromb Res. 2020 Jul;191:9-14
pubmed: 32353746
Rev Soc Bras Med Trop. 2020 Jun 03;53:e20200307
pubmed: 32520236
Lancet Neurol. 2020 May;19(5):383-384
pubmed: 32246917
Int J Neurosci. 2021 Dec;131(12):1243-1247
pubmed: 32543260
Stroke. 2009 Jun;40(6):2031-6
pubmed: 19228858
Front Neurol. 2020 Apr 21;11:353
pubmed: 32373061
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
J Neurol. 2020 Aug;267(8):2185-2192
pubmed: 32436105
J Neurointerv Surg. 2020 Jul;12(7):648-653
pubmed: 32451359
N Engl J Med. 2016 Sep 15;375(11):e26
pubmed: 27626542
J Clin Neurosci. 2020 Jul;77:227-229
pubmed: 32409210
J Neurol Sci. 2020 Jun 15;413:116814
pubmed: 32259707
J Am Coll Cardiol. 2020 Jul 7;76(1):122-124
pubmed: 32387623
N Engl J Med. 2020 Feb 20;382(8):727-733
pubmed: 31978945
Rev Neurol (Paris). 2020 Jun;176(6):516-518
pubmed: 32334841
JAMA. 2020 Mar 17;323(11):1061-1069
pubmed: 32031570
IDCases. 2020 Apr 18;20:e00771
pubmed: 32313807
Thromb Res. 2011 Mar;127(3):198-201
pubmed: 21216444
J Stroke Cerebrovasc Dis. 2020 Aug;29(8):104984
pubmed: 32689588
Radiology. 2020 Aug;296(2):E119-E120
pubmed: 32228363
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
J Crit Care. 2020 Oct;59:32-34
pubmed: 32512349
J Clin Neurosci. 2020 Jul;77:234-236
pubmed: 32414622
Thromb Res. 2020 Jul;191:148-150
pubmed: 32381264
J Clin Epidemiol. 2012 Sep;65(9):934-9
pubmed: 22742910
Stroke. 2020 Jul;51(7):e124-e127
pubmed: 32396456
J Neurol Neurosurg Psychiatry. 2020 Aug;91(8):889-891
pubmed: 32354768
N Engl J Med. 2004 Dec 16;351(25):2611-8
pubmed: 15602021
Stroke. 2020 Aug;51(8):2540-2543
pubmed: 32466736
Ann Clin Transl Neurol. 2018 Mar 14;5(4):456-463
pubmed: 29687022
J Neurol. 2020 Jul;267(7):1877-1879
pubmed: 32333166
AJNR Am J Neuroradiol. 2020 Jul;41(7):1179-1183
pubmed: 32467191
Stroke. 2011 Jul;42(7):1851-6
pubmed: 21546476
Neurol Neuroimmunol Neuroinflamm. 2020 Apr 29;7(4):
pubmed: 32350026
Neurology. 2020 Aug 25;95(8):e1060-e1070
pubmed: 32482845
Intensive Care Med. 2020 Jun;46(6):1089-1098
pubmed: 32367170
BMJ. 2020 May 22;369:m1966
pubmed: 32444366
BMJ. 2020 Mar 26;368:m1091
pubmed: 32217556
J Clin Med. 2019 Sep 13;8(9):
pubmed: 31540205
Cureus. 2020 May 14;12(5):e8121
pubmed: 32426200
N Engl J Med. 2020 Jun 25;382(26):2574-2576
pubmed: 32302082
J Thromb Thrombolysis. 2020 Oct;50(3):543-547
pubmed: 32519165
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Acad Emerg Med. 2016 Oct;23(10):1128-1135
pubmed: 27313141
Brain Behav Immun. 2020 Jul;87:115-119
pubmed: 32360439
Eur J Neurol. 2020 Sep;27(9):e38-e39
pubmed: 32503080
J Clin Neurosci. 2020 Jun;76:233-235
pubmed: 32312628
N Engl J Med. 2020 Apr 23;382(17):e38
pubmed: 32268022
Lancet. 2020 Feb 15;395(10223):507-513
pubmed: 32007143
QJM. 2020 Aug 1;113(8):573-574
pubmed: 32442268
J Neurointerv Surg. 2020 Jul;12(7):669-672
pubmed: 32430481
Circulation. 2017 Mar 7;135(10):e146-e603
pubmed: 28122885
Eur J Neurol. 2020 Sep;27(9):e35-e36
pubmed: 32352618
Curr Probl Cardiol. 2020 Aug;45(8):100617
pubmed: 32402515
N Engl J Med. 2020 May 14;382(20):e60
pubmed: 32343504
JAMA Neurol. 2020 Jun 1;77(6):683-690
pubmed: 32275288
JAMA Neurol. 2020 Jul 02;:
pubmed: 32614385