Epitope-Specific Antibody Responses to a Plasmodium falciparum Subunit Vaccine Target in a Malaria-Endemic Population.
Plasmodium falciparum
circumsporozoite protein
malaria
peptide microarray
Journal
The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675
Informations de publication
Date de publication:
04 06 2021
04 06 2021
Historique:
received:
09
06
2020
accepted:
25
09
2020
pubmed:
30
9
2020
medline:
12
2
2022
entrez:
29
9
2020
Statut:
ppublish
Résumé
Circumsporozoite protein (CSP) coats the Plasmodium falciparum sporozoite surface and is a major malaria subunit vaccine target. We measured epitope-specific reactivity to field-derived CSP haplotypes in serum samples from Malian adults and children on a custom peptide microarray. Compared to children, adults showed greater antibody responses and responses to more variants in regions proximal to and within the central repeat region. Children acquired short-lived immunity to an epitope proximal to the central repeat region but not to the central repeat region itself. This approach has the potential to differentiate immunodominant from protective epitope-specific responses when combined with longitudinal infection data.
Identifiants
pubmed: 32992328
pii: 5913015
doi: 10.1093/infdis/jiaa611
pmc: PMC8176638
doi:
Substances chimiques
Antibodies, Protozoan
0
Epitopes
0
Malaria Vaccines
0
Protozoan Proteins
0
Vaccines, Subunit
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1943-1947Subventions
Organisme : NIAID NIH HHS
ID : T32 AI007524
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI110820
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI119733
Pays : United States
Organisme : FIC NIH HHS
ID : D43 TW001589
Pays : United States
Organisme : NIAID NIH HHS
ID : K23 AI125720
Pays : United States
Organisme : NHLBI NIH HHS
ID : K01 HL140285
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI065683
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL130750
Pays : United States
Organisme : NIAID NIH HHS
ID : N01AI85346
Pays : United States
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
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