Thapsigargin at Non-Cytotoxic Levels Induces a Potent Host Antiviral Response that Blocks Influenza A Virus Replication.
Animals
Antiviral Agents
/ pharmacology
Cell Line
Chick Embryo
Chlorocebus aethiops
Dogs
Endoplasmic Reticulum Stress
/ drug effects
Female
Host-Pathogen Interactions
/ drug effects
Humans
Immunity, Innate
/ drug effects
Influenza A Virus, H1N1 Subtype
/ growth & development
Influenza A Virus, H3N8 Subtype
/ growth & development
Influenza, Human
/ drug therapy
Interferon Type I
/ drug effects
Interferons
/ drug effects
Mice
Mice, Inbred BALB C
Sarcoplasmic Reticulum Calcium-Transporting ATPases
/ antagonists & inhibitors
Swine
Thapsigargin
/ pharmacology
Unfolded Protein Response
/ drug effects
Vero Cells
Virus Replication
/ drug effects
Interferon Lambda
antiviral
endoplasmic reticulum stress
influenza A virus
innate immunity
thapsigargin
unfolded protein response
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
27 09 2020
27 09 2020
Historique:
received:
01
09
2020
revised:
21
09
2020
accepted:
24
09
2020
entrez:
30
9
2020
pubmed:
1
10
2020
medline:
17
2
2021
Statut:
epublish
Résumé
Influenza A virus is a major global pathogen of humans, and there is an unmet need for effective antivirals. Current antivirals against influenza A virus directly target the virus and are vulnerable to mutational resistance. Harnessing an effective host antiviral response is an attractive alternative. We show that brief exposure to low, non-toxic doses of thapsigargin (TG), an inhibitor of the sarcoplasmic/endoplasmic reticulum (ER) Ca
Identifiants
pubmed: 32992478
pii: v12101093
doi: 10.3390/v12101093
pmc: PMC7600819
pii:
doi:
Substances chimiques
Antiviral Agents
0
Interferon Type I
0
Thapsigargin
67526-95-8
Interferons
9008-11-1
Sarcoplasmic Reticulum Calcium-Transporting ATPases
EC 3.6.3.8
Interferon Lambda
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MC_PC_18058
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/L015293/1
Pays : United Kingdom
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