Venous Thromboembolism and Its Risk Factors in Children with Acute Lymphoblastic Leukemia in Israel: A Population-Based Study.
acute lymphoblastic leukemia
hypertriglyceridemia
risk factors
sinus vein thrombosis
thrombophilia
venous thromboembolism
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
25 Sep 2020
25 Sep 2020
Historique:
received:
30
08
2020
revised:
22
09
2020
accepted:
22
09
2020
entrez:
30
9
2020
pubmed:
1
10
2020
medline:
1
10
2020
Statut:
epublish
Résumé
Venous thromboembolism (VTE) is a serious complication of acute lymphoblastic leukemia (ALL) therapy. The aim of this population-based study was to evaluate the rate, risk factors, and long-term sequelae of VTE in children treated for ALL. The cohort included 1191 children aged 1-19 years diagnosed with ALL between 2003-2018, prospectively enrolled in two consecutive protocols: ALL-IC BFM 2002 and AIEOP-BFM ALL 2009. VTEs occurred in 89 patients (7.5%). Long-term sequelae were uncommon. By univariate analysis, we identified four significant risk factors for VTEs: Severe hypertriglyceridemia (
Identifiants
pubmed: 32992771
pii: cancers12102759
doi: 10.3390/cancers12102759
pmc: PMC7600511
pii:
doi:
Types de publication
Journal Article
Langues
eng
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