Glutathione Supplementation as an Adjunctive Therapy in COVID-19.
COVID-19
IL-6
TNF-α
cytokines
glutathione
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
25 Sep 2020
25 Sep 2020
Historique:
received:
04
08
2020
revised:
14
09
2020
accepted:
20
09
2020
entrez:
30
9
2020
pubmed:
1
10
2020
medline:
1
10
2020
Statut:
epublish
Résumé
Morbidity and mortality of coronavirus disease 2019 (COVID-19) are due in large part to severe cytokine storm and hypercoagulable state brought on by dysregulated host-inflammatory immune response, ultimately leading to multi-organ failure. Exacerbated oxidative stress caused by increased levels of interleukin (IL)-6 and tumor necrosis factor α (TNF-α) along with decreased levels of interferon α and interferon β (IFN-α, IFN-β) are mainly believed to drive the disease process. Based on the evidence attesting to the ability of glutathione (GSH) to inhibit viral replication and decrease levels of IL-6 in human immunodeficiency virus (HIV) and tuberculosis (TB) patients, as well as beneficial effects of GSH on other pulmonary diseases processes, we believe the use of liposomal GSH could be beneficial in COVID-19 patients. This review discusses the epidemiology, transmission, and clinical presentation of COVID-19 with a focus on its pathogenesis and the possible use of liposomal GSH as an adjunctive treatment to the current treatment modalities in COVID-19 patients.
Identifiants
pubmed: 32992775
pii: antiox9100914
doi: 10.3390/antiox9100914
pmc: PMC7601802
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : NHLBI NIH HHS
ID : R15 HL143545
Pays : United States
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