PKM2 Determines Myofiber Hypertrophy In Vitro and Increases in Response to Resistance Exercise in Human Skeletal Muscle.
Warburg effect
cancer
glycolysis
hypertrophy
insulin-like growth factor 1
metabolic reprogramming
pyruvate kinase
resistance exercise
skeletal muscle
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
25 Sep 2020
25 Sep 2020
Historique:
received:
09
08
2020
revised:
21
09
2020
accepted:
23
09
2020
entrez:
30
9
2020
pubmed:
1
10
2020
medline:
26
2
2021
Statut:
epublish
Résumé
Nearly 100 years ago, Otto Warburg investigated the metabolism of growing tissues and discovered that tumors reprogram their metabolism. It is poorly understood whether and how hypertrophying muscle, another growing tissue, reprograms its metabolism too. Here, we studied pyruvate kinase muscle (PKM), which can be spliced into two isoforms (PKM1, PKM2). This is of interest, because PKM2 redirects glycolytic flux towards biosynthetic pathways, which might contribute to muscle hypertrophy too. We first investigated whether resistance exercise changes PKM isoform expression in growing human skeletal muscle and found that PKM2 abundance increases after six weeks of resistance training, whereas PKM1 decreases. Second, we determined that
Identifiants
pubmed: 32992783
pii: ijms21197062
doi: 10.3390/ijms21197062
pmc: PMC7583908
pii:
doi:
Substances chimiques
Carrier Proteins
0
Membrane Proteins
0
Thyroid Hormones
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fedeal Institute of Sports Sciences (BISP)
ID : BISP AZ 070106/16-17 / BISP IIA1-070112/13-14
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