Intercellular Transmission of Naked Viruses through Extracellular Vesicles: Focus on Polyomaviruses.


Journal

Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722

Informations de publication

Date de publication:
26 09 2020
Historique:
received: 28 08 2020
revised: 20 09 2020
accepted: 23 09 2020
entrez: 30 9 2020
pubmed: 1 10 2020
medline: 17 2 2021
Statut: epublish

Résumé

Extracellular vesicles have recently emerged as a novel mode of viral transmission exploited by naked viruses to exit host cells through a nonlytic pathway. Extracellular vesicles can allow multiple viral particles to collectively traffic in and out of cells, thus enhancing the viral fitness and diversifying the transmission routes while evading the immune system. This has been shown for several RNA viruses that belong to the Picornaviridae, Hepeviridae, Reoviridae, and Caliciviridae families; however, recent studies also demonstrated that the BK and JC viruses, two DNA viruses that belong to the Polyomaviridae family, use a similar strategy. In this review, we provide an update on recent advances in understanding the mechanisms used by naked viruses to hijack extracellular vesicles, and we discuss the implications for the biology of polyomaviruses.

Identifiants

pubmed: 32993049
pii: v12101086
doi: 10.3390/v12101086
pmc: PMC7599864
pii:
doi:

Substances chimiques

Antibodies, Neutralizing 0
Antibodies, Viral 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Francois Helle (F)

UR UPJV 4294, Agents Infectieux, Résistance et chimiothérapie (AGIR), Centre Universitaire de Recherche en Santé, Université de Picardie Jules Verne, 80000 Amiens, France.

Lynda Handala (L)

UR UPJV 4294, Agents Infectieux, Résistance et chimiothérapie (AGIR), Centre Universitaire de Recherche en Santé, Université de Picardie Jules Verne, 80000 Amiens, France.
Laboratoire de Virologie, Centre Hospitalier Universitaire, 80000 Amiens, France.

Marine Bentz (M)

UR UPJV 4294, Agents Infectieux, Résistance et chimiothérapie (AGIR), Centre Universitaire de Recherche en Santé, Université de Picardie Jules Verne, 80000 Amiens, France.

Gilles Duverlie (G)

UR UPJV 4294, Agents Infectieux, Résistance et chimiothérapie (AGIR), Centre Universitaire de Recherche en Santé, Université de Picardie Jules Verne, 80000 Amiens, France.
Laboratoire de Virologie, Centre Hospitalier Universitaire, 80000 Amiens, France.

Etienne Brochot (E)

UR UPJV 4294, Agents Infectieux, Résistance et chimiothérapie (AGIR), Centre Universitaire de Recherche en Santé, Université de Picardie Jules Verne, 80000 Amiens, France.
Laboratoire de Virologie, Centre Hospitalier Universitaire, 80000 Amiens, France.

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