Sex-Specific Control of Muscle Mass: Elevated IGFBP Proteolysis and Reductions of IGF-1 Levels Are Associated with Substantial Loss of Carcass Weight in Male DU6PxIGFBP-2 Transgenic Mice.
Animals
Female
Gene Expression Regulation, Developmental
/ genetics
Humans
Insulin-Like Growth Factor Binding Protein 2
/ genetics
Insulin-Like Growth Factor Binding Proteins
/ genetics
Insulin-Like Growth Factor I
/ genetics
Male
Mice
Mice, Transgenic
/ genetics
Muscle, Skeletal
/ growth & development
Phenotype
Proteolysis
Sex Characteristics
IGF-1
IGFBP-2
carcass weight
muscle accretion
phenotype selection
proteolytic activity
sex
transgenic mouse
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
26 09 2020
26 09 2020
Historique:
received:
28
08
2020
revised:
18
09
2020
accepted:
25
09
2020
entrez:
30
9
2020
pubmed:
1
10
2020
medline:
22
6
2021
Statut:
epublish
Résumé
In farmed animals, carcass weight represents an important economic trait. Since we had demonstrated that IGFBP-2 represents a potent inhibitor of muscle accretion in inbred mice, we wanted to quantify the inhibitory effects of IGFBP-2 under conditions of elevated protein mass in growth selected non-inbred mice (DU6P). Therefore, we crossed male DU6P mice with female IGFBP-2 transgenic mice. Male IGFBP-2 transgenic offspring (DU6P/IGFBP-2) were characterized by more than 20% reductions of carcass mass compared to male non-transgenic littermates. The carcass mass in males was also significantly lower (
Identifiants
pubmed: 32993096
pii: cells9102174
doi: 10.3390/cells9102174
pmc: PMC7600981
pii:
doi:
Substances chimiques
Insulin-Like Growth Factor Binding Protein 2
0
Insulin-Like Growth Factor Binding Proteins
0
Insulin-Like Growth Factor I
67763-96-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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