Activation of Gingival Fibroblasts by Bacterial Cyclic Dinucleotides and Lipopolysaccharide.
human gingival fibroblasts
inflammation
interleukin
lipopolysaccharide
matrix metalloproteinases
Journal
Pathogens (Basel, Switzerland)
ISSN: 2076-0817
Titre abrégé: Pathogens
Pays: Switzerland
ID NLM: 101596317
Informations de publication
Date de publication:
26 Sep 2020
26 Sep 2020
Historique:
received:
27
07
2020
revised:
27
08
2020
accepted:
24
09
2020
entrez:
30
9
2020
pubmed:
1
10
2020
medline:
1
10
2020
Statut:
epublish
Résumé
Human gingival fibroblasts (HGFs) recognize microbe-associated molecular patterns (MAMPs) and respond with inflammatory proteins. Simultaneous impacts of bacterial cyclic di-guanosine monophosphate (c-di-GMP), cyclic di-adenosine monophosphate (c-di-AMP), and lipopolysaccharide (LPS) on gingival keratinocytes have been previously demonstrated, but the effects of these MAMPs on other periodontal cell types, such as gingival fibroblasts, remain to be clarified. The present aim was to examine the independent and combined effects of these cyclic dinucleotides and LPS on interleukin (IL) and matrix metalloproteinase (MMP) response of HGFs. The cells were incubated with c-di-GMP and c-di-AMP, either in the presence or absence of
Identifiants
pubmed: 32993127
pii: pathogens9100792
doi: 10.3390/pathogens9100792
pmc: PMC7600373
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Turku University Foundation
ID : 2018
Organisme : Suomen Hammaslääkäriseura Apollonia
ID : 2019
Organisme : Minerva Foundation, Finland
ID : 2018
Organisme : National Science Foundation, USA
ID : CHE 2004102
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