Repeat tick exposure elicits distinct immune responses in guinea pigs and mice.
Ixodes scapularis
Lyme disease
RNA-sequencing
Tick immunity
Tick saliva
Vaccine
Journal
Ticks and tick-borne diseases
ISSN: 1877-9603
Titre abrégé: Ticks Tick Borne Dis
Pays: Netherlands
ID NLM: 101522599
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
17
04
2020
revised:
23
07
2020
accepted:
24
07
2020
entrez:
30
9
2020
pubmed:
1
10
2020
medline:
30
6
2021
Statut:
ppublish
Résumé
Ticks deposit salivary proteins into the skin during a bite to mediate acquisition of a blood meal. Acquired resistance to tick bites has been demonstrated to prevent Borrelia burgdorferi sensu lato (s.l.) transmission. However, the mechanism of resistance, as well as the protective antigens, have remained elusive. To address these unknowns, we utilized a guinea pig model of tick resistance and a mouse model of permissiveness. Guinea pigs developed immunity after multiple Ixodes scapularis tick infestations, characterized by rapid tick detachment and impaired feeding. In comparison, mice tolerated at least 6 infestations with no significant impact on feeding. We analyzed the bite sites by RNA-sequencing and histology, identifying several inflammatory pathways in tick immune animals, such as FcεRI signaling and complement activation, and activation of coagulation pathways that could impair local blood flow. Together, these results identify important pathways altered during tick rejection and potential tick proteins that could serve as vaccine candidates.
Identifiants
pubmed: 32993942
pii: S1877-959X(20)30195-3
doi: 10.1016/j.ttbdis.2020.101529
pmc: PMC7530331
mid: NIHMS1619736
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101529Subventions
Organisme : NIAID NIH HHS
ID : P01 AI138949
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI032947
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007974
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier GmbH. All rights reserved.
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