Read, Write, Adapt: Challenges and Opportunities during Kinetoplastid Genome Replication.

Animals DNA Replication DNA, Kinetoplast / genetics Genome, Protozoan Kinetoplastida / genetics Leishmania / genetics Trypanosoma brucei brucei / genetics
DNA repair DNA replication adaptation antigenic variation kinetoplastid

Journal

Trends in genetics : TIG
ISSN: 0168-9525
Titre abrégé: Trends Genet
Pays: England
ID NLM: 8507085

Informations de publication

Date de publication:
01 2021
Historique:
received: 17 06 2020
revised: 31 08 2020
accepted: 01 09 2020
pubmed: 1 10 2020
medline: 3 7 2021
entrez: 30 9 2020
Statut: ppublish

Résumé

The genomes of all organisms are read throughout their growth and development, generating new copies during cell division and encoding the cellular activities dictated by the genome's content. However, genomes are not invariant information stores but are purposefully altered in minor and major ways, adapting cellular behaviour and driving evolution. Kinetoplastids are eukaryotic microbes that display a wide range of such read-write genome activities, in many cases affecting critical aspects of their biology, such as host adaptation. Here we discuss the range of read-write genome changes found in two well-studied kinetoplastid parasites, Trypanosoma brucei and Leishmania, focusing on recent work that suggests such adaptive genome variation is linked to novel strategies the parasites use to replicate their unconventional genomes.

Identifiants

DOI: 10.1016/j.tig.2020.09.002 PMID: 32993968 PMC: PMC9213392
pubmed: 32993968
pii: S0168-9525(20)30238-9
doi: 10.1016/j.tig.2020.09.002
pmc: PMC9213392
pii:
doi:

Substances chimiques

DNA, Kinetoplast 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

21-34

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 104111
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S019472/1
Pays : United Kingdom

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.

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Auteurs

Jeziel D Damasceno (JD)

The Wellcome Centre for Integrative Parasitology, University of Glasgow, Institute of Infection, Immunity and Inflammation, Sir Graeme Davies Building, 120 University Place, Glasgow, G12 8TA, UK. Electronic address: Jeziel.damasceno@glasgow.ac.uk.

Catarina A Marques (CA)

The Wellcome Centre for Integrative Parasitology, University of Glasgow, Institute of Infection, Immunity and Inflammation, Sir Graeme Davies Building, 120 University Place, Glasgow, G12 8TA, UK.

Jennifer Black (J)

The Wellcome Centre for Integrative Parasitology, University of Glasgow, Institute of Infection, Immunity and Inflammation, Sir Graeme Davies Building, 120 University Place, Glasgow, G12 8TA, UK.

Emma Briggs (E)

The Wellcome Centre for Integrative Parasitology, University of Glasgow, Institute of Infection, Immunity and Inflammation, Sir Graeme Davies Building, 120 University Place, Glasgow, G12 8TA, UK; Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3FL, UK.

Richard McCulloch (R)

The Wellcome Centre for Integrative Parasitology, University of Glasgow, Institute of Infection, Immunity and Inflammation, Sir Graeme Davies Building, 120 University Place, Glasgow, G12 8TA, UK. Electronic address: Richard.mcculloch@glasgow.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Read, Write, Adapt: Challenges and...
questionsmedicales.fr › Phénomènes génétiques › Réplication de l'ADN › Read, Write, Adapt: Challenges and...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN des protozoaires › ADN kinétoplastique › Read, Write, Adapt: Challenges and...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome de protozoaire › Read, Write, Adapt: Challenges and...
questionsmedicales.fr › Eucaryotes › Euglénozoaires › Kinetoplastida › Read, Write, Adapt: Challenges and...
questionsmedicales.fr › Eucaryotes › Euglénozoaires › Kinetoplastida › Trypanosomatina › Leishmania › Read, Write, Adapt: Challenges and...
questionsmedicales.fr › Eucaryotes › Euglénozoaires › Kinetoplastida › Trypanosomatina › Trypanosoma › Trypanosoma brucei brucei › Read, Write, Adapt: Challenges and...