Control of skeletal morphogenesis by the Hippo-YAP/TAZ pathway.
Adaptor Proteins, Signal Transducing
/ metabolism
Animals
Bone and Bones
/ abnormalities
Cartilage
/ pathology
Cell Cycle Proteins
/ metabolism
Cell Nucleus
/ metabolism
Cell Proliferation
Chondrocytes
/ metabolism
Cleft Palate
/ pathology
Extracellular Matrix
/ genetics
Gene Expression Regulation, Developmental
Growth Plate
/ pathology
Hippo Signaling Pathway
Mice
Mice, Inbred C57BL
Mice, Knockout
Morphogenesis
/ genetics
Protein Serine-Threonine Kinases
/ metabolism
Signal Transduction
Trans-Activators
/ metabolism
Tumor Suppressor Proteins
/ metabolism
YAP-Signaling Proteins
Cartilage
Hippo pathway
Mouse embryo
TAZ
YAP
Journal
Development (Cambridge, England)
ISSN: 1477-9129
Titre abrégé: Development
Pays: England
ID NLM: 8701744
Informations de publication
Date de publication:
12 11 2020
12 11 2020
Historique:
received:
06
12
2019
accepted:
07
09
2020
pubmed:
1
10
2020
medline:
29
12
2020
entrez:
30
9
2020
Statut:
epublish
Résumé
The Hippo-YAP/TAZ pathway is an important regulator of tissue growth, but can also control cell fate or tissue morphogenesis. Here, we investigate the function of the Hippo pathway during the development of cartilage, which forms the majority of the skeleton. Previously, YAP was proposed to inhibit skeletal size by repressing chondrocyte proliferation and differentiation. We find that,
Identifiants
pubmed: 32994166
pii: dev.187187
doi: 10.1242/dev.187187
pmc: PMC7673359
pii:
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
Cell Cycle Proteins
0
Trans-Activators
0
Tumor Suppressor Proteins
0
Wwtr1 protein, mouse
0
YAP-Signaling Proteins
0
Yap1 protein, mouse
0
Lats1 protein, mouse
EC 2.7.1.-
LATS2 protein, mouse
EC 2.7.11.1
Protein Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : FC001180
Pays : United Kingdom
Organisme : Wellcome Trust
ID : FC001180
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Cancer Research UK
ID : FC001180
Pays : United Kingdom
Organisme : Francis Crick Institute
ID : FC001180
Pays : International
Informations de copyright
© 2020. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing or financial interests.
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