Mutation-independent Proteomic Signatures of Pathological Progression in Murine Models of Duchenne Muscular Dystrophy.
Duchenne muscular dystrophy
dystrophin
gene expression
iTRAQ
mdx
mdx52
neurodegenerative diseases
proteomics
quantification
tandem mass spectrometry
Journal
Molecular & cellular proteomics : MCP
ISSN: 1535-9484
Titre abrégé: Mol Cell Proteomics
Pays: United States
ID NLM: 101125647
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
09
09
2020
pubmed:
1
10
2020
medline:
12
8
2021
entrez:
30
9
2020
Statut:
ppublish
Résumé
The absence of the dystrophin protein in Duchenne muscular dystrophy (DMD) results in myofiber fragility and a plethora of downstream secondary pathologies. Although a variety of experimental therapies are in development, achieving effective treatments for DMD remains exceptionally challenging, not least because the pathological consequences of dystrophin loss are incompletely understood. Here we have performed proteome profiling in tibialis anterior muscles from two murine DMD models (
Identifiants
pubmed: 32994316
pii: S1535-9476(20)60011-1
doi: 10.1074/mcp.RA120.002345
pmc: PMC7710136
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2047-2068Subventions
Organisme : Medical Research Council
Pays : United Kingdom
Informations de copyright
© 2020 van Westering et al.
Déclaration de conflit d'intérêts
Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
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