Uptake and predictors of colonoscopy use in family members not participating in cascade genetic testing for Lynch syndrome.
Adult
Colonic Neoplasms
/ genetics
Colonoscopy
/ trends
Colorectal Neoplasms, Hereditary Nonpolyposis
/ diagnosis
Cross-Sectional Studies
Family
Female
Genetic Predisposition to Disease
/ genetics
Genetic Testing
/ trends
Health Knowledge, Attitudes, Practice
Heterozygote
Humans
Male
Middle Aged
Mutation
/ genetics
Risk Factors
United States
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
29 09 2020
29 09 2020
Historique:
received:
13
02
2020
accepted:
03
09
2020
entrez:
30
9
2020
pubmed:
1
10
2020
medline:
5
1
2021
Statut:
epublish
Résumé
Cascade genetic testing provides a method to appropriately focus colonoscopy use in families with Lynch syndrome (LS). However, research suggests that up to two-thirds at risk to inherit LS don't participate. Within the United States, no studies have assessed colonoscopy use within this elusive and high-risk subset. We set forth to (1) document colonoscopy use within those not undergoing genetic testing (NGT) and (2) identify factors associated with completing colonoscopy. Data came from a cross sectional survey of families with molecularly confirmed LS. One hundred seventy-six (176) adults participated; 47 of unknown variant status and 129 with variant status known (59 carriers/70 non-carriers). Despite a high level of awareness of LS (85%) and identical recommendations for colonoscopy, NGT reported significantly lower use of colonoscopy than carriers (47% vs. 73%; p = 0.003). Our results show that perceived risk to develop colon cancer (AOR = 1.99, p < 0.05) and physician recommendations (AOR = 7.64, p < 0.01) are significant predictors of colonoscopy use across all family members controlling for carrier status. Given these findings, health care providers, should assess patients' perceived risk to develop cancer, assist them in adjusting risk perceptions and discuss recommendations for colonoscopy with all members in families with LS.Trial Registration Clinical Trials.gov Identifier: NCT00004210.
Identifiants
pubmed: 32994442
doi: 10.1038/s41598-020-72938-z
pii: 10.1038/s41598-020-72938-z
pmc: PMC7525436
doi:
Banques de données
ClinicalTrials.gov
['NCT00004210']
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
15959Références
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