Unraveling the Possible Routes of SARS-COV-2 Invasion into the Central Nervous System.
CNS penetration
COVID-19
Coronaviruses (CoVs)
Neuroinvasion
Neurological manifestations
Neurotropism
Neurovirulence
Pandemic
SARS-2
SARS-CoV-2
Journal
Current treatment options in neurology
ISSN: 1092-8480
Titre abrégé: Curr Treat Options Neurol
Pays: United States
ID NLM: 9815940
Informations de publication
Date de publication:
2020
2020
Historique:
accepted:
07
09
2020
entrez:
30
9
2020
pubmed:
1
10
2020
medline:
1
10
2020
Statut:
ppublish
Résumé
To describe the possible neuroinvasion pathways of Severe Acute Respiratory Syndrome-related Coronavirus-2 (SARS-CoV-2), the virus responsible for the Coronavirus disease-19 (Covid-19) pandemic. We present data regarding the family of Coronaviruses (CoVs) and the central nervous system (CNS), and describe parallels between SARS-CoV-2 and other members of the family, which have been investigated in more depth and combine these findings with the recent advancements regarding SARS-CoV-2. SARS-CoV-2 like other CoVs is neuroinvasive, neurotropic and neurovirulent. Two main pathways of CNS penetration seem to be the strongest candidates, the hematogenous and the neuronal. Τhe olfactory route in particular appears to play a significant role in neuroinvasion of coronaviruses and SARS-CoV-2, as well. However, existing data suggest that other routes, involving the nasal epithelium in general, lymphatic tissue and the CSF may also play roles in SARS-CoV-2 invasion into the CNS.
Identifiants
pubmed: 32994698
doi: 10.1007/s11940-020-00647-z
pii: 647
pmc: PMC7515807
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
37Informations de copyright
© Springer Science+Business Media, LLC, part of Springer Nature 2020.
Déclaration de conflit d'intérêts
Conflict of InterestThe authors declare that they have no conflict of interest.
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