Association of superoxide dismutase enzyme with staging and grade of differentiation colorectal cancer: A cross-sectional study.
Antioxidant
Colorectal cancer
Neoplasm grading
Superoxide dismutase
Journal
Annals of medicine and surgery (2012)
ISSN: 2049-0801
Titre abrégé: Ann Med Surg (Lond)
Pays: England
ID NLM: 101616869
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
10
08
2020
accepted:
17
08
2020
entrez:
30
9
2020
pubmed:
1
10
2020
medline:
1
10
2020
Statut:
epublish
Résumé
The increase of superoxide dismutase (SOD) level in colorectal cancer (CRC) patients based on the examination of staging and grade of differentiation still evidently represents a clinical problem. SOD level raises at a certain staging and reduce at a certain grade of differentiation. For that reason, this study aimed to assess the association between SOD and the variables analyzed in this study. This study was observational study using a cross-sectional research design aimed to measure the association between SOD and staging as well as grade of differentiation in CRC incidence. The study was conducted in our institution from January until March 2018. Statistical analyses of the data derived from the laboratory indicated that age and histopathological examination (TNM staging) had statistically significant correlation with SOD1 level. This significant correlation was proven from results of the statistical analyses of each variable at p = 0.039 (age) and p = 0.001 (TNM staging) respectively. Subsequent tests concerning the correlation between age and TNM staging on SOD1 level revealed that the study samples in the category of 30-49 age years old showed statistically significant correlation with SOD1 level with p = 0.009. The increase of grade of differentiation was proportional to the increase of SOD1 level as antioxidant against cancer in CRC patients.
Identifiants
pubmed: 32994983
doi: 10.1016/j.amsu.2020.08.032
pii: S2049-0801(20)30278-8
pmc: PMC7505864
doi:
Types de publication
Journal Article
Langues
eng
Pagination
194-199Informations de copyright
© 2020 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no conflict of interests.
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