Primary B-Cell lymphoma of the uterine cervix presenting with right ureter hydronephrosis: A case report.

Female genital tract lymphoma Hydronephrosis Non-Hodgkin's lymphoma Pelvic mass differential diagnosis R-CHOP regimen Uterine cervix lymphoma

Journal

Gynecologic oncology reports
ISSN: 2352-5789
Titre abrégé: Gynecol Oncol Rep
Pays: Netherlands
ID NLM: 101652231

Informations de publication

Date de publication:
Nov 2020
Historique:
received: 23 07 2020
revised: 02 09 2020
accepted: 06 09 2020
entrez: 30 9 2020
pubmed: 1 10 2020
medline: 1 10 2020
Statut: epublish

Résumé

Primary lymphoma of the uterine cervix is a very infrequent disease, usually affecting perimenopausal women. Symptoms are very similar to other gynecological malignancies, but treatment and prognosis completely differ, as most of these patients have a better survival. This condition has to be suspected in women with recent normal Pap smear test, rapidly growing tumor and initially non-contributory biopsies. We report a case of primary diffuse large-B-cell lymphoma of the uterine cervix mimicking a locally advanced cervical cancer with right ureter hydronephrosis at diagnosis. She was medically managed with a combination of rituximab and chemotherapy with cyclophosphamide, hydroxydaunorubicin, oncovin, and prednisone, associated to methotrexate for central nervous system prophylaxis. We will discuss about the role of combined treatments with surgery and radiotherapy, and the fertility sparing management in young women.

Identifiants

pubmed: 32995453
doi: 10.1016/j.gore.2020.100639
pii: S2352-5789(20)30105-3
pmc: PMC7508993
doi:

Types de publication

Case Reports

Langues

eng

Pagination

100639

Informations de copyright

© 2020 Institut Claudius Regaud - IUCT-Oncopole.

Déclaration de conflit d'intérêts

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Références

J Ultrasound Med. 2013 Apr;32(4):717-8
pubmed: 23525399
Case Rep Radiol. 2014;2014:157268
pubmed: 24864220
Am J Transl Res. 2019 Sep 15;11(9):5800-5811
pubmed: 31632549
N Engl J Med. 2002 Jan 24;346(4):235-42
pubmed: 11807147
Case Rep Hematol. 2012;2012:326127
pubmed: 23091747
Obstet Gynecol. 2011 Feb;117(2 Pt 2):444-446
pubmed: 21252783
Int J Gynecol Pathol. 2006 Jan;25(1):1-21
pubmed: 16306779
Eur J Cancer. 2013 Apr;49(6):1374-403
pubmed: 23485231
J Comput Assist Tomogr. 2018 May/Jun;42(3):435-440
pubmed: 29369946
Am J Obstet Gynecol. 2005 Sep;193(3 Pt 1):866-72
pubmed: 16150291
Lancet. 2003 Jul 12;362(9378):139-46
pubmed: 12867117
Br J Radiol. 2004 Jun;77(918):512-5
pubmed: 15151974
Gynecol Oncol. 2017 May;145(2):305-309
pubmed: 28284518

Auteurs

Mathilde Del (M)

Department of Surgical Oncology, Institut Claudius Regaud - Institut Universitaire du Cancer de Toulouse (IUCT) - Oncopole, Toulouse, France.

Martina Aida Angeles (MA)

Department of Surgical Oncology, Institut Claudius Regaud - Institut Universitaire du Cancer de Toulouse (IUCT) - Oncopole, Toulouse, France.

Charlotte Syrykh (C)

Department of Pathology, Institut Claudius Regaud - Institut Universitaire du Cancer de Toulouse (IUCT) - Oncopole, Toulouse, France.

Carlos Martínez-Gómez (C)

Department of Surgical Oncology, Institut Claudius Regaud - Institut Universitaire du Cancer de Toulouse (IUCT) - Oncopole, Toulouse, France.
INSERM CRCT Team 1, Tumor Immunology and Immunotherapy, Toulouse, France.

Alejandra Martínez (A)

Department of Surgical Oncology, Institut Claudius Regaud - Institut Universitaire du Cancer de Toulouse (IUCT) - Oncopole, Toulouse, France.
INSERM CRCT Team 1, Tumor Immunology and Immunotherapy, Toulouse, France.

Gwénaël Ferron (G)

Department of Surgical Oncology, Institut Claudius Regaud - Institut Universitaire du Cancer de Toulouse (IUCT) - Oncopole, Toulouse, France.
INSERM CRCT Team 19, ONCOSARC - Oncogenesis of sarcomas, Toulouse, France.

Erwan Gabiache (E)

Department of Nuclear Medicine, Institut Claudius Regaud - Institut Universitaire du Cancer de Toulouse (IUCT) - Oncopole, Toulouse, France.

Lucie Oberic (L)

Department of Hematology, Institut Claudius Regaud - Institut Universitaire du Cancer de Toulouse (IUCT) - Oncopole, Toulouse, France.

Classifications MeSH