Importance of MMP-8 in Salivary and Gingival Crevicular Fluids of Periodontitis Patients.
Journal
Iranian journal of immunology : IJI
ISSN: 1735-367X
Titre abrégé: Iran J Immunol
Pays: Iran
ID NLM: 101282932
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
entrez:
30
9
2020
pubmed:
1
10
2020
medline:
2
7
2021
Statut:
ppublish
Résumé
Matrix metalloproteinases (MMPs) stimulate alveolar bone loss in chronic periodontitis. To evaluate the salivary and gingival crevicular fluid (GCF) levels of MMP-8 in patients with moderate to severe chronic periodontitis. 42 participants were divided into two groups: a case group (21 patients with generalized moderate to severe chronic periodontitis) and a control group (21 healthy periodontal subjects). GCF and saliva samples were obtained from both groups. Salivary and GCF MMP-8 levels of each subject were detected using the ELISA method. Mean±SD values of salivary MMP-8 levels of the control and case groups were 1.52 ± 0.65 ng/ml and 6.06 ± 1.18 ng/ml, respectively, and statistically significant difference was observed (p=0.0001). Also, mean±SD values of GCF MMP-8 levels of the control and case groups were 0.87 ± 0.26 ng/ml and 2.92 ± 0.64 ng/ml, respectively; which was statistically significant (p=0.0001). Our results demonstrate an increased concentration of salivary and GCF levels of MMP-8 in the patient group.
Sections du résumé
BACKGROUND
BACKGROUND
Matrix metalloproteinases (MMPs) stimulate alveolar bone loss in chronic periodontitis.
OBJECTIVE
OBJECTIVE
To evaluate the salivary and gingival crevicular fluid (GCF) levels of MMP-8 in patients with moderate to severe chronic periodontitis.
METHODS
METHODS
42 participants were divided into two groups: a case group (21 patients with generalized moderate to severe chronic periodontitis) and a control group (21 healthy periodontal subjects). GCF and saliva samples were obtained from both groups. Salivary and GCF MMP-8 levels of each subject were detected using the ELISA method.
RESULTS
RESULTS
Mean±SD values of salivary MMP-8 levels of the control and case groups were 1.52 ± 0.65 ng/ml and 6.06 ± 1.18 ng/ml, respectively, and statistically significant difference was observed (p=0.0001). Also, mean±SD values of GCF MMP-8 levels of the control and case groups were 0.87 ± 0.26 ng/ml and 2.92 ± 0.64 ng/ml, respectively; which was statistically significant (p=0.0001).
CONCLUSION
CONCLUSIONS
Our results demonstrate an increased concentration of salivary and GCF levels of MMP-8 in the patient group.
Identifiants
pubmed: 32996900
pii: 06
doi: 10.22034/iji.2020.81170.1512
doi:
Substances chimiques
Biomarkers
0
Matrix Metalloproteinase 8
EC 3.4.24.34
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM