Therapeutic drug monitoring of children and adolescents treated with aripiprazole: observational results from routine patient care.
Aripiprazole
Children
Pharmacovigilance
Schizophrenia
Serum concentration
TDM
Journal
Journal of neural transmission (Vienna, Austria : 1996)
ISSN: 1435-1463
Titre abrégé: J Neural Transm (Vienna)
Pays: Austria
ID NLM: 9702341
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
31
05
2020
accepted:
10
09
2020
pubmed:
1
10
2020
medline:
16
10
2021
entrez:
30
9
2020
Statut:
ppublish
Résumé
Although aripiprazole is one of the most used antipsychotics, knowledge about serum concentrations in children and adolescents is scarce and age-specific therapeutic ranges have not been established yet. Data of a routine therapeutic drug monitoring service were analyzed in order to evaluate the relationship between dose and serum concentration of aripiprazole in children and adolescents. The study also aimed to evaluate whether the therapeutic reference range defined for adults with schizophrenia (100-350 ng/ml) is applicable for minors. Data from 130 patients (aged 7-19 years) treated with aripiprazole for different indications in doses of 2-30 mg/day were evaluated. Patient characteristics, doses, serum concentrations and therapeutic outcome were assessed by standardized measures. A positive mean correlation between body weight-corrected daily dose and aripiprazole concentration was found (r
Identifiants
pubmed: 32997183
doi: 10.1007/s00702-020-02253-4
pii: 10.1007/s00702-020-02253-4
doi:
Substances chimiques
Antipsychotic Agents
0
Aripiprazole
82VFR53I78
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM