Voltage-gating of aquaporins, a putative conserved safety mechanism during ionic stresses.
drought stress
gating
membrane permeability
molecular dynamics
water channel
Journal
FEBS letters
ISSN: 1873-3468
Titre abrégé: FEBS Lett
Pays: England
ID NLM: 0155157
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
16
09
2020
accepted:
19
09
2020
pubmed:
1
10
2020
medline:
8
7
2021
entrez:
30
9
2020
Statut:
ppublish
Résumé
Aquaporins are transmembrane water channels found in almost every living organism. Numerous studies have brought a good understanding of both water transport through their pores and the regulations taking place at the molecular level, but subtleties remain to be clarified. Recently, a voltage-related gating mechanism involving the conserved arginine of the channel's main constriction was captured for human aquaporins through molecular dynamics studies. With a similar approach, we show that this voltage-gating could be conserved among this family and that the underlying mechanism could explain part of plant AQPs diversity when contextualized to high ionic concentrations provoked by drought. Finally, we identified residues as adaptive traits which constitute good targets for drought resistance plant breeding research.
Identifiants
pubmed: 32997337
doi: 10.1002/1873-3468.13944
doi:
Substances chimiques
Aquaporins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
41-57Informations de copyright
© 2020 Federation of European Biochemical Societies.
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