Response of patients with chest tightness variant asthma with routine asthma treatment regimen: A 1-year multicenter, prospective, real-world study.

chest tightness variant asthma inhaled corticosteroids long-acting beta-agonists real-world study

Journal

Clinical and translational medicine
ISSN: 2001-1326
Titre abrégé: Clin Transl Med
Pays: United States
ID NLM: 101597971

Informations de publication

Date de publication:
Sep 2020
Historique:
received: 15 08 2020
revised: 01 09 2020
accepted: 03 08 2020
entrez: 30 9 2020
pubmed: 1 10 2020
medline: 1 10 2020
Statut: ppublish

Résumé

Asthmatic patients with chest tightness as their only presenting symptom (chest tightness variant asthma [CTVA]) have clinical characteristics of eosinophilic airway inflammation similar to those of classic asthma (CA); however, whether CTVA has similar response to antiasthma treatment as compared with CA remains unclear. The response of 76 CTVA patients to standard asthma treatments with inhaled corticosteroids with long-acting beta-agonists was explored in a 52-week multicenter, prospective, real-world study. After 52 weeks of treatment with therapy regimens used for CA, the mean 5-point Asthma Control Questionnaire (ACQ-5) score decreased markedly from 1.38(first administration) to 0.71 (52 weeks, mean decrease: 0.674, 95%CI: 0.447-0.900, P<.001).The mean asthma quality-of-life questionnaire (AQLQ) score increased from 5.77 (first administration) to 6.20 (52 weeks, mean increase: 0.441, 95% CI 0.258-0.625, P<.001). Furthermore, at week 52, FVC, FEV In conclusion, patients with CTVA had a good therapeutic response to the guideline-recommended routine treatment (containing inhaled corticosteroids). The association between the treatment response and the severity of CTVA suggested that CTVA patients with higher ACQ-5 scores had better therapeutic effects.

Sections du résumé

BACKGROUND BACKGROUND
Asthmatic patients with chest tightness as their only presenting symptom (chest tightness variant asthma [CTVA]) have clinical characteristics of eosinophilic airway inflammation similar to those of classic asthma (CA); however, whether CTVA has similar response to antiasthma treatment as compared with CA remains unclear.
OBJECTIVE OBJECTIVE
The response of 76 CTVA patients to standard asthma treatments with inhaled corticosteroids with long-acting beta-agonists was explored in a 52-week multicenter, prospective, real-world study.
RESULTS RESULTS
After 52 weeks of treatment with therapy regimens used for CA, the mean 5-point Asthma Control Questionnaire (ACQ-5) score decreased markedly from 1.38(first administration) to 0.71 (52 weeks, mean decrease: 0.674, 95%CI: 0.447-0.900, P<.001).The mean asthma quality-of-life questionnaire (AQLQ) score increased from 5.77 (first administration) to 6.20 (52 weeks, mean increase: 0.441, 95% CI 0.258-0.625, P<.001). Furthermore, at week 52, FVC, FEV
CONCLUSION CONCLUSIONS
In conclusion, patients with CTVA had a good therapeutic response to the guideline-recommended routine treatment (containing inhaled corticosteroids). The association between the treatment response and the severity of CTVA suggested that CTVA patients with higher ACQ-5 scores had better therapeutic effects.

Identifiants

DOI: 10.1002/ctm2.178 PMID: 32997402 PMC: PMC7503098
pubmed: 32997402
doi: 10.1002/ctm2.178
pmc: PMC7503098
doi:

Types de publication

Letter

Langues

eng

Pagination

e178

Subventions

Organisme : Zhejiang Medical and Health Science and Technology program from Health Commission of Zhejiang Province
ID : WKJ2014-ZJ-01412
Organisme : Precision Medicine Research of the National Key Research and Development Plan of China
ID : 2016YFC0905800

Informations de copyright

© 2020 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

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Auteurs

Fugui Yan (F)

Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Wen Li (W)

Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Wei-Jie Guan (WJ)

Department of Respiratory Medicine, State Key Laboratory of Respiratory Disease, Guangzhou Institute for Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Min Chen (M)

Department of Respiratory Medicine, Affiliated Hospital, Guangdong Medical University, Zhanjiang, China.

Chen Qiu (C)

Department of Respiratory Medicine, Shenzhen People's Hospital, Shenzhen, China.

Wei Tang (W)

Department of Respiratory Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Xiansheng Liu (X)

Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Xudong Xiang (X)

Department of Respiratory Medicine, Second Xiangya Hospital, Central South University, Changsha, China.

Jing Li (J)

Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, The First Hospital, Guangzhou Medical University, Guangzhou, China.

Meiling Jin (M)

Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

Yuanrong Dai (Y)

Department of Pulmonary Medicine, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Ping Chen (P)

Department of Pulmonary Medicine, General Hospital of Northern Theater Command of the Chinese People's Liberation Army, Shenyang, China.

Xiaohong Wu (X)

Department of Pulmonary Medicine, Affiliated Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Zhongmin Qiu (Z)

Department of Pulmonary Medicine, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.

Liang Dong (L)

Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan, China.

Limin Zhao (L)

Department of Pulmonary Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.

Xiaoping Lin (X)

Department of Pulmonary Medicine, Second Affiliated Hospital of Fujian Medical University, Fujian, China.

Changgui Wu (C)

Department of Respiratory Disease, Xijing Hospital, The Fourth Military Medical University, Xian, China.

Bin Wu (B)

Department of Respiratory Medicine, Affiliated Hospital, Guangdong Medical University, Zhanjiang, China.

Yalian Yuan (Y)

Department of Respiratory Medicine, Affiliated Hospital, Guangdong Medical University, Zhanjiang, China.

Fei Shi (F)

Department of Respiratory Medicine, Shenzhen People's Hospital, Shenzhen, China.

Ting Zhang (T)

Department of Respiratory Medicine, Shenzhen People's Hospital, Shenzhen, China.

Jun Zhou (J)

Department of Respiratory Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Min Xie (M)

Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Xiaoyu Fang (X)

Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Hongliang Zhang (H)

Department of Respiratory Medicine, Second Xiangya Hospital, Central South University, Changsha, China.

Bing Xiao (B)

Department of Respiratory Medicine, Second Xiangya Hospital, Central South University, Changsha, China.

Mo Xian (M)

Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, The First Hospital, Guangzhou Medical University, Guangzhou, China.

Jian Wang (J)

Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

Zhangwei Qiu (Z)

Department of Pulmonary Medicine, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Jie Lin (J)

Department of Pulmonary Medicine, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Bingbing Ji (B)

Department of Pulmonary Medicine, General Hospital of Northern Theater Command of the Chinese People's Liberation Army, Shenyang, China.

Yong Zhou (Y)

Department of Pulmonary Medicine, Affiliated Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Yu Li (Y)

Department of Pulmonary Medicine, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.

Chunhong Liu (C)

Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan, China.

Yiping Chen (Y)

Department of Pulmonary Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.

Yiming Zeng (Y)

Department of Pulmonary Medicine, Second Affiliated Hospital of Fujian Medical University, Fujian, China.
ORCID: 0000-0001-5635-3006

Lingli Liu (L)

Department of Respiratory Disease, Xijing Hospital, The Fourth Military Medical University, Xian, China.

Wen Hua (W)

Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Huaqiong Huang (H)

Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Jiesen Zhou (J)

Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Yue Hu (Y)

Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Luanqing Che (L)

Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Songmin Ying (S)

Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Zhihua Chen (Z)

Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Nanshan Zhong (N)

Department of Respiratory Medicine, State Key Laboratory of Respiratory Disease, Guangzhou Institute for Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Huahao Shen (H)

Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
ORCID: 0000-0001-9546-9351

Classifications MeSH