Effect of Hydrophilic Monomer Distribution on Self-Assembly of a pH-Responsive Copolymer: Spheres, Worms and Vesicles from a Single Copolymer Composition.
copolymer
gradient copolymer
self-assembly
sequence control
stimuli-responsive
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
23 Feb 2021
23 Feb 2021
Historique:
received:
31
07
2020
revised:
24
09
2020
pubmed:
1
10
2020
medline:
1
10
2020
entrez:
30
9
2020
Statut:
ppublish
Résumé
A series of copolymers containing 50 mol % acrylic acid (AA) and 50 mol % butyl acrylate (BA) but with differing composition profiles ranging from an AA-BA diblock copolymer to a linear gradient poly(AA-grad-BA) copolymer were synthesized and their pH-responsive self-assembly behavior was investigated. While assemblies of the AA-BA diblock copolymer were kinetically frozen, the gradient-like compositions underwent reversible changes in size and morphology in response to changes in pH. In particular, a diblock copolymer consisting of two random copolymer segments of equal length (16 mol % and 84 mol % AA content, respectively) formed spherical micelles at pH >5, a mix of spherical and wormlike micelles at pH 5 and vesicles at pH 4. These assemblies were characterized by dynamic light scattering, cryo-transmission electron microscopy and small angle neutron scattering.
Identifiants
pubmed: 32997426
doi: 10.1002/anie.202010501
pmc: PMC7984367
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4925-4930Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : GU 1685/1-1
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB1278, projects B01 and Z01
Organisme : Agence Nationale de la Recherche
ID : ANR-15-CE08-0039
Organisme : National Natural Science Foundation of China
ID : 21901208
Organisme : Natural Science Basic Research Plan in Shaanxi Province
ID : 2020JQ-138
Organisme : Consejo Nacional de Ciencia y Tecnología
ID : CVU 626293
Organisme : Consejo Nacional de Ciencia y Tecnología
ID : 471816
Informations de copyright
© 2020 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.
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