Super-relaxed state of myosin in human skeletal muscle is fiber-type dependent.


Journal

American journal of physiology. Cell physiology
ISSN: 1522-1563
Titre abrégé: Am J Physiol Cell Physiol
Pays: United States
ID NLM: 100901225

Informations de publication

Date de publication:
01 12 2020
Historique:
pubmed: 1 10 2020
medline: 8 1 2021
entrez: 30 9 2020
Statut: ppublish

Résumé

The myosin super-relaxed state (SRX) in skeletal muscle is hypothesized to play an important role in regulating muscle contractility and thermogenesis in humans but has only been examined in model organisms. Here we report the first human skeletal muscle SRX measurements, using quantitative epifluorescence microscopy of fluorescent 2'/3'-

Identifiants

pubmed: 32997515
doi: 10.1152/ajpcell.00396.2020
pmc: PMC7792673
doi:

Substances chimiques

Protein Isoforms 0
Myosin Heavy Chains EC 3.6.4.1

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

C1158-C1162

Subventions

Organisme : NIA NIH HHS
ID : R01 AG062899
Pays : United States
Organisme : NIA NIH HHS
ID : K02 AG036827
Pays : United States
Organisme : NIA NIH HHS
ID : R37 AG026160
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG029796
Pays : United States
Organisme : NIA NIH HHS
ID : R03 AG025861
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR032961
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG031743
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG026160
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG047245
Pays : United States
Organisme : NIA NIH HHS
ID : F30 AG057108
Pays : United States
Organisme : NIA NIH HHS
ID : K01 AG020990
Pays : United States
Organisme : NIA NIH HHS
ID : F32 AG005815
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008244
Pays : United States

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Auteurs

Lien A Phung (LA)

Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota.

Aurora D Foster (AD)

Department of Kinesiology, University of Massachusetts, Amherst, Massachusetts.

Mark S Miller (MS)

Department of Kinesiology, University of Massachusetts, Amherst, Massachusetts.

Dawn A Lowe (DA)

Department of Rehabilitation Medicine, University of Minnesota, Minneapolis, Minnesota.

David D Thomas (DD)

Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota.

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Classifications MeSH