Haploinsufficiency of cohesin protease, Separase, promotes regeneration of hematopoietic stem cells in mice.
ESPL1
Separase
cohesin
haploinsufficiency
hematopoiesis
hematopoietic stem cells
mouse model
Journal
Stem cells (Dayton, Ohio)
ISSN: 1549-4918
Titre abrégé: Stem Cells
Pays: England
ID NLM: 9304532
Informations de publication
Date de publication:
30 Sep 2020
30 Sep 2020
Historique:
received:
21
02
2019
revised:
23
07
2020
accepted:
31
08
2020
pubmed:
1
10
2020
medline:
1
10
2020
entrez:
30
9
2020
Statut:
aheadofprint
Résumé
Cohesin recently emerged as a new regulator of hematopoiesis and leukemia. In addition to cohesin, whether proteins that regulate cohesin's function have any direct role in hematopoiesis and hematologic diseases have not been fully examined. Separase, encoded by the ESPL1 gene, is an important regulator of cohesin's function. Canonically, protease activity of Separase resolves sister chromatid cohesion by cleaving cohesin subunit-Rad21 at the onset of anaphase. Using a Separase haploinsufficient mouse model, we have uncovered a novel role of Separase in hematopoiesis. We report that partial disruption of Separase distinctly alters the functional characteristics of hematopoietic stem/progenitor cells (HSPCs). Although analyses of peripheral blood and bone marrow of Espl1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Cancer Prevention and Research Institute of Texas
ID : RP160022
Organisme : T32 Pediatric Hematology Research Training Program
Informations de copyright
© 2020 AlphaMed Press.
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