Investigation of a Pharmacological Approach for Reduction of Renal Uptake of Radiolabeled ADAPT Scaffold Protein.
ADAPT
kidney
radionuclide
reabsorption
renal uptake
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
28 Sep 2020
28 Sep 2020
Historique:
received:
17
08
2020
revised:
25
09
2020
accepted:
25
09
2020
entrez:
1
10
2020
pubmed:
2
10
2020
medline:
20
3
2021
Statut:
epublish
Résumé
Albumin binding domain-Derived Affinity ProTeins (ADAPTs) are small (5 kDa) engineered scaffold proteins that are promising targeting agents for radionuclide-based imaging. A recent clinical study has demonstrated that radiolabeled ADAPTs can efficiently visualize human epidermal growth factor receptor 2 (HER2) expression in breast cancer using SPECT imaging. However, the use of ADAPTs directly labeled with radiometals for targeted radionuclide therapy is limited by their high reabsorption and prolonged retention of activity in kidneys. In this study, we investigated whether a co-injection of lysine or gelofusin, commonly used for reduction of renal uptake of radiolabeled peptides in clinics, would reduce the renal uptake of [
Identifiants
pubmed: 32998229
pii: molecules25194448
doi: 10.3390/molecules25194448
pmc: PMC7583817
pii:
doi:
Substances chimiques
Proteins
0
Radiopharmaceuticals
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Science and Higher Education of the Russian Federation
ID : 075-15-2019-1925
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