The Protective Effect of Exercise in Neurodegenerative Diseases: The Potential Role of Extracellular Vesicles.
Alzheimer’s disease
exercise
exosomes
extracellular vesicles
neurodegenerative diseases
physical activity
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
28 09 2020
28 09 2020
Historique:
received:
11
08
2020
revised:
18
09
2020
accepted:
23
09
2020
entrez:
1
10
2020
pubmed:
2
10
2020
medline:
22
6
2021
Statut:
epublish
Résumé
Physical activity has systemic effects on the body, affecting almost every organ. It is important not only for general health and wellbeing, but also in the prevention of diseases. The mechanisms behind the therapeutic effects of physical activity are not completely understood; however, studies indicate these benefits are not confined to simply managing energy balance and body weight. They also include systemic factors which are released into the circulation during exercise and which appear to underlie the myriad of benefits exercise can elicit. It was shown that along with a number of classical cytokines, active tissues also engage in inter-tissue communication via extracellular vesicles (EVs), specifically exosomes and other small EVs, which are able to deliver biomolecules to cells and alter their metabolism. Thus, EVs may play a role in the acute and systemic adaptations that take place during and after physical activity, and may be therapeutically useful in the treatment of a range of diseases, including metabolic disorders such as type 2 diabetes and obesity; and the focus of this review, neurological disorders such as Alzheimer's disease.
Identifiants
pubmed: 32998245
pii: cells9102182
doi: 10.3390/cells9102182
pmc: PMC7599526
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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