Vasoactive Intestinal Polypeptide (VIP) in the Intestinal Mucosal Nerve Fibers in Dogs with Inflammatory Bowel Disease.
VIP
digestive tract
dogs
enteric nervous system
immunohistochemistry
Journal
Animals : an open access journal from MDPI
ISSN: 2076-2615
Titre abrégé: Animals (Basel)
Pays: Switzerland
ID NLM: 101635614
Informations de publication
Date de publication:
28 Sep 2020
28 Sep 2020
Historique:
received:
11
09
2020
accepted:
25
09
2020
entrez:
1
10
2020
pubmed:
2
10
2020
medline:
2
10
2020
Statut:
epublish
Résumé
Canine inflammatory bowel disease (IBD) is a group of enteropathies with nonspecific chronic symptoms and poorly understood etiology. Many aspects connected with IBD are not understood. One of them is the participation of the intestinal nervous system in the development of pathological processes. Thus, this study aimed to demonstrate changes in the density of intramucosal nerve fibers containing vasoactive intestinal polypeptide (VIP)-one of the most important intestinal nervous factors caused by the various stages of IBD development. Mucosal biopsy specimens collected from the duodenum, jejunum and descending colon of healthy dogs and dogs with varied severity of IBD were included in the experiment. The density of VIP-like immunoreactive (VIP-LI) nerves was determined by a single immunofluorescence technique and a semi-quantitative method consisting in VIP-LI fiber counts in the field of view (0.1 mm
Identifiants
pubmed: 32998326
pii: ani10101759
doi: 10.3390/ani10101759
pmc: PMC7599766
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Minister of Science and Higher Education in the framework of the program entitled "Regional Initiative of Excellence" for the years 2019-2022
ID : Project No. 010/RID/2018/19
Organisme : National Center for Research and Development
ID : No. N N308 234938
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