Salt, water, and vasopressin in polycystic kidney disease.
Journal
Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
21
05
2020
revised:
29
05
2020
accepted:
01
06
2020
entrez:
1
10
2020
pubmed:
2
10
2020
medline:
22
6
2021
Statut:
ppublish
Résumé
Excessive salt intake and vasopressin may promote cyst growth in autosomal dominant polycystic kidney disease and glomerular filtration rate (GFR) decline in chronic kidney disease. Kramers et al. confirmed the effects of salt in a large autosomal dominant polycystic kidney disease cohort. Copeptin mediated 72% and 25% of the salt effects on GFR decline and kidney growth. Kidney growth did not significantly contribute to the copeptin-mediated salt effect on GFR. Differences in kidney growth and GFR decline trajectories and factors other than cyst growth contributing to GFR decline may explain the divergent effects.
Identifiants
pubmed: 32998813
pii: S0085-2538(20)30635-9
doi: 10.1016/j.kint.2020.06.001
pii:
doi:
Substances chimiques
Biomarkers
0
Glycopeptides
0
Sodium Chloride, Dietary
0
Water
059QF0KO0R
Vasopressins
11000-17-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
831-834Informations de copyright
Copyright © 2020 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.