Journal
Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086
Informations de publication
Date de publication:
30 09 2020
30 09 2020
Historique:
received:
31
10
2019
accepted:
06
05
2020
entrez:
1
10
2020
pubmed:
2
10
2020
medline:
24
6
2021
Statut:
ppublish
Résumé
Postinfectious hydrocephalus (PIH), which often follows neonatal sepsis, is the most common cause of pediatric hydrocephalus worldwide, yet the microbial pathogens underlying this disease remain to be elucidated. Characterization of the microbial agents causing PIH would enable a shift from surgical palliation of cerebrospinal fluid (CSF) accumulation to prevention of the disease. Here, we examined blood and CSF samples collected from 100 consecutive infant cases of PIH and control cases comprising infants with non-postinfectious hydrocephalus in Uganda. Genomic sequencing of samples was undertaken to test for bacterial, fungal, and parasitic DNA; DNA and RNA sequencing was used to identify viruses; and bacterial culture recovery was used to identify potential causative organisms. We found that infection with the bacterium
Identifiants
pubmed: 32998967
pii: 12/563/eaba0565
doi: 10.1126/scitranslmed.aba0565
pmc: PMC7774825
mid: NIHMS1609375
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI145057
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA LM000073
Pays : United States
Organisme : Intramural NIH HHS
ID : Z99 LM999999
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR002015
Pays : United States
Organisme : Medical Research Council
ID : MR/M017990/1
Pays : United Kingdom
Organisme : NICHD NIH HHS
ID : DP1 HD086071
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA220523
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 LM000073
Pays : United States
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
Références
Trends Immunol. 2015 Oct;36(10):569-577
pubmed: 26431936
Sci Rep. 2018 Feb 23;8(1):3551
pubmed: 29476058
Mol Aspects Med. 2012 Feb;33(1):14-25
pubmed: 22061966
Microbiome. 2018 Dec 17;6(1):226
pubmed: 30558668
J Infect Dis. 2002 Feb 1;185(3):273-82
pubmed: 11807708
Exp Toxicol Pathol. 2003 Sep;55(2-3):91-106
pubmed: 14620530
J R Coll Surg Edinb. 1976 Jul;21(4):222-4
pubmed: 966194
Exp Toxicol Pathol. 2004 Jul;55(6):413-31
pubmed: 15384248
Int J Syst Evol Microbiol. 2008 Mar;58(Pt 3):682-7
pubmed: 18319478
Int J Syst Evol Microbiol. 2002 Nov;52(Pt 6):2241-9
pubmed: 12508893
Nat Biotechnol. 2017 Nov;35(11):1077-1086
pubmed: 28967885
J Neurosurg. 2018 Apr 1;:1-15
pubmed: 29701543
BMJ Glob Health. 2018 Jan 12;3(1):e000347
pubmed: 29564153
Ann Clin Lab Sci. 2008 Autumn;38(4):393-400
pubmed: 18988935
Evid Based Complement Alternat Med. 2006 Mar;3(1):49-59
pubmed: 16550223
J Pediatr. 2012 Nov;161(5):843-7
pubmed: 22703952
Intern Med J. 2014 Sep;44(9):911-5
pubmed: 25201422
N Engl J Med. 2017 Dec 21;377(25):2456-2464
pubmed: 29262276
J Neurosurg Pediatr. 2012 Sep;10(3):161-7
pubmed: 22768966
J Neurosurg Pediatr. 2018 May;21(5):478-485
pubmed: 29498607
Front Nutr. 2016 Jun 14;3:16
pubmed: 27379239
Nucleic Acids Res. 2018 Jul 2;46(W1):W282-W288
pubmed: 29905870
J Neurosurg. 2005 Jan;102(1 Suppl):1-15
pubmed: 16206728
Exp Toxicol Pathol. 2004 Jul;55(6):433-49
pubmed: 15384249
J Neurosurg Pediatr. 2011 Jan;7(1):73-87
pubmed: 21194290
Clin Microbiol Rev. 1996 Jan;9(1):18-33
pubmed: 8665474
Semin Fetal Neonatal Med. 2007 Jun;12(3):207-13
pubmed: 17483042
Antonie Van Leeuwenhoek. 1993-1994;64(3-4):253-60
pubmed: 8085788
Nat Methods. 2013 Dec;10(12):1200-2
pubmed: 24076764
mBio. 2015 Sep 22;6(5):e01491-15
pubmed: 26396248
Lancet Glob Health. 2014 Jun;2(6):e334-45
pubmed: 25103302
Int J Syst Evol Microbiol. 2007 Jan;57(Pt 1):81-91
pubmed: 17220447
Microbiome. 2019 Apr 16;7(1):62
pubmed: 30992055
Pediatr Infect Dis J. 2016 Mar;35(3):358
pubmed: 26866854
Br Med J. 1890 Aug 16;2(1546):380-3
pubmed: 20753110
Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):E7128-37
pubmed: 26621750
PLoS One. 2014 Jun 11;9(2):e98819
pubmed: 24919177
Nat Rev Neurol. 2020 May;16(5):285-296
pubmed: 32152460
J Neurosurg Pediatr. 2015 Feb;15(2):113-24
pubmed: 25431902
Clin Infect Dis. 2020 Jul 27;71(3):525-531
pubmed: 31504335
Clin Infect Dis. 2019 Jan 7;68(2):266-272
pubmed: 29868873
Nat Methods. 2010 May;7(5):335-6
pubmed: 20383131
J Neurosurg Pediatr. 2011 Nov;8(5):509-21
pubmed: 22044378
Neuroradiology. 1978;16:31-5
pubmed: 310982
Nat Rev Dis Primers. 2018 Feb 01;4:17107
pubmed: 29388572
Cytometry B Clin Cytom. 2016 Jul;90(4):376-86
pubmed: 26130241
Microbiol Resour Announc. 2020 Apr 9;9(15):
pubmed: 32273361
PLoS One. 2013 Aug 27;8(8):e72775
pubmed: 24013829
BMC Biol. 2014 Nov 12;12:87
pubmed: 25387460
Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2567-72
pubmed: 15701695