Late attentional processes potentially compensate for early perceptual multisensory integration deficits in children with autism: evidence from evoked potentials.
Acoustic Stimulation
Adolescent
Attention
/ physiology
Auditory Perception
/ physiology
Autism Spectrum Disorder
/ physiopathology
Brain
/ physiopathology
Child
Electroencephalography
Evoked Potentials
/ physiology
Female
Humans
Male
Photic Stimulation
Reaction Time
/ physiology
Visual Perception
/ physiology
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
30 09 2020
30 09 2020
Historique:
received:
17
04
2020
accepted:
12
08
2020
entrez:
1
10
2020
pubmed:
2
10
2020
medline:
29
12
2020
Statut:
epublish
Résumé
Sensory processing deficits and altered long-range connectivity putatively underlie Multisensory Integration (MSI) deficits in Autism Spectrum Disorder (ASD). The present study set out to investigate non-social MSI stimuli and their electrophysiological correlates in young neurotypical adolescents and adolescents with ASD. We report robust MSI effects at behavioural and electrophysiological levels. Both groups demonstrated normal behavioural MSI. However, at the neurophysiological level, the ASD group showed less MSI-related reduction of the visual P100 latency, greater MSI-related slowing of the auditory P200 and an overall temporally delayed and spatially constrained onset of MSI. Given the task design and patient sample, and the age of our participants, we argue that electro-cortical indices of MSI deficits in ASD: (a) can be detected in early-adolescent ASD, (b) occur at early stages of perceptual processing, (c) can possibly be compensated by later attentional processes, (d) thus leading to normal MSI at the behavioural level.
Identifiants
pubmed: 32999327
doi: 10.1038/s41598-020-73022-2
pii: 10.1038/s41598-020-73022-2
pmc: PMC7527489
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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