Tumoural activation of TLR3-SLIT2 axis in endothelium drives metastasis.
Animals
Breast Neoplasms
/ metabolism
Chemotaxis
Disease Models, Animal
Disease Progression
Endothelial Cells
/ metabolism
Endothelium
/ metabolism
Female
Humans
Intercellular Signaling Peptides and Proteins
/ genetics
Lung Neoplasms
/ metabolism
Male
Mice
Neoplasm Metastasis
/ genetics
Nerve Tissue Proteins
/ genetics
RNA, Double-Stranded
Receptors, Immunologic
/ genetics
Signal Transduction
Toll-Like Receptor 3
/ deficiency
Tumor Cells, Cultured
Roundabout Proteins
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
06
09
2018
accepted:
02
07
2020
pubmed:
2
10
2020
medline:
15
12
2020
entrez:
1
10
2020
Statut:
ppublish
Résumé
Blood vessels support tumours by providing nutrients and oxygen, while also acting as conduits for the dissemination of cancer
Identifiants
pubmed: 32999457
doi: 10.1038/s41586-020-2774-y
pii: 10.1038/s41586-020-2774-y
pmc: PMC8088828
mid: NIHMS1691936
doi:
Substances chimiques
Intercellular Signaling Peptides and Proteins
0
Nerve Tissue Proteins
0
RNA, Double-Stranded
0
Receptors, Immunologic
0
Toll-Like Receptor 3
0
Slit homolog 2 protein
R6FXH13RRC
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
299-304Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM123977
Pays : United States
Organisme : NIH HHS
ID : R01CA24098
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA240984
Pays : United States
Organisme : NIH HHS
ID : R01-CA236954-01A1
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA236954
Pays : United States
Références
Strilic, B. et al. Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis. Nature 536, 215–218 (2016).
pubmed: 27487218
Png, K. J., Halberg, N., Yoshida, M. & Tavazoie, S. F. A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells. Nature 481, 190–194 (2012).
Pencheva, N. et al. Convergent multi-miRNA targeting of ApoE drives LRP1/LRP8-dependent melanoma metastasis and angiogenesis. Cell 151, 1068–1082 (2012).
pubmed: 23142051
pmcid: 3753115
Pencheva, N. & Tavazoie, S. F. Control of metastatic progression by microRNA regulatory networks. Nat. Cell Biol. 15, 546–554 (2013).
pubmed: 23728460
pmcid: 4678324
Rafii, S., Butler, J. M. & Ding, B. S. Angiocrine functions of organ-specific endothelial cells. Nature 529, 316–325 (2016).
pubmed: 26791722
pmcid: 4878406
Kobayashi, H. et al. Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells. Nat. Cell Biol. 12, 1046–1056 (2010).
pubmed: 20972423
pmcid: 2972406
Ding, B. S. et al. Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization. Cell 147, 539–553 (2011).
pubmed: 22036563
pmcid: 3228268
Ding, B. S. et al. Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration. Nature 468, 310–315 (2010).
pubmed: 21068842
pmcid: 3058628
Tavora, B. et al. Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy. Nature 514, 112–116 (2014).
pubmed: 25079333
pmcid: 4533916
Sanz, E. et al. Cell-type-specific isolation of ribosome-associated mRNA from complex tissues. Proc. Natl Acad. Sci. USA 106, 13939–13944 (2009).
pubmed: 19666516
pmcid: 2728999
Wang, Y. et al. Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature 465, 483–486 (2010).
pubmed: 20445537
Gibson, D. A. et al. Dendrite self-avoidance requires cell-autonomous Slit/Robo signaling in cerebellar purkinje cells. Neuron 81, 1040–1056 (2014).
pubmed: 24607227
pmcid: 3963503
Brose, K. et al. Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Cell 96, 795–806 (1999).
pubmed: 10102268
Wang, K. H. et al. Biochemical purification of a mammalian Slit protein as a positive regulator of sensory axon elongation and branching. Cell 96, 771–784 (1999).
pubmed: 10102266
Strickland, P., Shin, G. C., Plump, A., Tessier-Lavigne, M. & Hinck, L. Slit2 and netrin 1 act synergistically as adhesive cues to generate tubular bi-layers during ductal morphogenesis. Development 133, 823–832 (2006).
pubmed: 16439476
Svensson, K. J. et al. A secreted Slit2 fragment regulates adipose tissue thermogenesis and metabolic function. Cell Metab. 23, 454–466 (2016).
pubmed: 26876562
pmcid: 4785066
Ballard, M. S. & Hinck, L. A roundabout way to cancer. Adv. Cancer Res. 114, 187–235 (2012).
pubmed: 22588058
pmcid: 4121377
Lang, J. E. et al. RNA-seq of circulating tumor cells in stage II–III breast cancer. Ann. Surg. Oncol. 25, 2261–2270 (2018).
pubmed: 29868978
pmcid: 7065419
Gantier, M. P. & Williams, B. R. The response of mammalian cells to double-stranded RNA. Cytokine Growth Factor Rev. 18, 363–371 (2007).
pubmed: 17698400
pmcid: 2084215
Johnsen, I. B. et al. Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling. EMBO J. 25, 3335–3346 (2006).
pubmed: 16858407
pmcid: 1523188
Itoh, K., Watanabe, A., Funami, K., Seya, T. & Matsumoto, M. The clathrin-mediated endocytic pathway participates in dsRNA-induced IFN-β production. J. Immunol. 181, 5522–5529 (2008).
pubmed: 18832709
Kawasaki, T. & Kawai, T. Toll-like receptor signaling pathways. Front. Immunol. 5, 461 (2014).
pubmed: 25309543
pmcid: 4174766
Shivapurkar, N. et al. Multiple regions of chromosome 4 demonstrating allelic losses in breast carcinomas. Cancer Res. 59, 3576–3580 (1999).
pubmed: 10446964
Dallol, A. et al. Frequent epigenetic inactivation of the SLIT2 gene in gliomas. Oncogene 22, 4611–4616 (2003).
pubmed: 12881718
Gröne, J. et al. Robo1/Robo4: differential expression of angiogenic markers in colorectal cancer. Oncol. Rep. 15, 1437–1443 (2006).
pubmed: 16685377
Huang, W. Y. et al. MethHC: a database of DNA methylation and gene expression in human cancer. Nucleic Acids Res. 43, D856–D861 (2015).
pubmed: 25398901
Macias, H. et al. SLIT/ROBO1 signaling suppresses mammary branching morphogenesis by limiting basal cell number. Dev. Cell 20, 827–840 (2011).
pubmed: 21664580
pmcid: 3129866
Macias, H. & Hinck, L. Mammary gland development. Wiley Interdiscip. Rev. Dev. Biol. 1, 533–557 (2012).
pubmed: 22844349
pmcid: 3404495
Marlow, R. et al. SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium. Cancer Res. 68, 7819–7827 (2008).
pubmed: 18829537
pmcid: 3075571
Escamilla-Tilch, M. et al. The interplay between pathogen-associated and danger-associated molecular patterns: an inflammatory code in cancer? Immunol. Cell Biol. 91, 601–610 (2013).
pubmed: 24100386
Bakhoum, S. F. et al. Chromosomal instability drives metastasis through a cytosolic DNA response. Nature 553, 467–472 (2018).
pubmed: 29342134
pmcid: 5785464
Nabet, B. Y. et al. Exosome RNA unshielding couples stromal activation to pattern recognition receptor signaling in cancer. Cell 170, 352–366 (2017).
pubmed: 28709002
pmcid: 6611169
Redzic, J. S., Balaj, L., van der Vos, K. E. & Breakefield, X. O. Extracellular RNA mediates and marks cancer progression. Semin. Cancer Biol. 28, 14–23 (2014).
pubmed: 24783980
Rooney, M. S., Shukla, S. A., Wu, C. J., Getz, G. & Hacohen, N. Molecular and genetic properties of tumors associated with local immune cytolytic activity. Cell 160, 48–61 (2015).
pubmed: 25594174
pmcid: 4856474
Kassiotis, G. Endogenous retroviruses and the development of cancer. J. Immunol. 192, 1343–1349 (2014).
pubmed: 24511094
Zernecke, A. & Preissner, K. T. Extracellular ribonucleic acids (RNA) enter the stage in cardiovascular disease. Circ. Res. 118, 469–479 (2016).
pubmed: 26846641
Khakpour, S., Wilhelmsen, K. & Hellman, J. Vascular endothelial cell Toll-like receptor pathways in sepsis. Innate Immun. 21, 827–846 (2015).
pubmed: 26403174
Mantovani, A., Allavena, P., Sica, A. & Balkwill, F. Cancer-related inflammation. Nature 454, 436–444 (2008).
pubmed: 18650914
Tavazoie, S. F. et al. Endogenous human microRNAs that suppress breast cancer metastasis. Nature 451, 147–152 (2008).
pubmed: 18185580
pmcid: 2782491
Reynolds, L. E. & Hodivala-Dilke, K. M. Primary mouse endothelial cell culture for assays of angiogenesis. Methods Mol. Med. 120, 503–509 (2006).
pubmed: 16491622
Aslakson, C. J. & Miller, F. R. Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor. Cancer Res. 52, 1399–1405 (1992).
pubmed: 1540948
Fidler, I. J. Biological behavior of malignant melanoma cells correlated to their survival in vivo. Cancer Res. 35, 218–224 (1975).
pubmed: 1109790
May, T. et al. Establishment of murine cell lines by constitutive and conditional immortalization. J. Biotechnol. 120, 99–110 (2005).
pubmed: 16026879
Guy, C. T., Cardiff, R. D. & Muller, W. J. Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol. Cell. Biol. 12, 954–961 (1992).
pubmed: 1312220
pmcid: 369527
Wagner, K. U. et al. Cre-mediated gene deletion in the mammary gland. Nucleic Acids Res. 25, 4323–4330 (1997).
pubmed: 9336464
pmcid: 147032
Lánczky, A. et al. miRpower: a web-tool to validate survival-associated miRNAs utilizing expression data from 2178 breast cancer patients. Breast Cancer Res. Treat. 160, 439–446 (2016).
pubmed: 27744485
DeRose, Y. S. et al. Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes. Nat. Med. 17, 1514–1520 (2011).
pubmed: 22019887
pmcid: 3553601
Sikora, M. J. et al. Invasive lobular carcinoma cell lines are characterized by unique estrogen-mediated gene expression patterns and altered tamoxifen response. Cancer Res. 74, 1463–1474 (2014).
pubmed: 24425047
pmcid: 3955299
Ponomarev, V. et al. A novel triple-modality reporter gene for whole-body fluorescent, bioluminescent, and nuclear noninvasive imaging. Eur. J. Nucl. Med. Mol. Imaging 31, 740–751 (2004).
pubmed: 15014901
Dhir, A. et al. Mitochondrial double-stranded RNA triggers antiviral signalling in humans. Nature 560, 238–242 (2018).
pubmed: 30046113
pmcid: 6570621